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TITLE:
Synthesis and characterization of PACAP23 glycopeptides for improved stability and transport - TFG:3780
Handle: https://hdl.handle.net/20.500.11797/TFG3780

Student:Varela Guerrero, Daniel
Language:en
Title in original language:Synthesis and characterization of PACAP23 glycopeptides for improved stability and transport
Title in different languages:Synthesis and characterization of PACAP23 glycopeptides for improved stability and transport
Keywords:PACAP23, Glycosylation
Subject:Química
Abstract:PAPAC38 and PACAP27 are endogenous peptides which have been studied for their properties against neurodegenerative diseases. Recently, it was studied if an easier to make version could also present these properties, and the results showed that PACAP23 was the shortest bioactive compound. Despite its positive effects, peptides present a series of drawbacks and a difficulty in crossing the BBB. Glycosylation has proved effective to help with these problems. Because of that, the success in the synthesis of a glycosylated PACAP23 could open a wide range of possibilities for the design of a drug meant for the treatment of these diseases.
Project director:Fernández Gutiérrez Mª Elena
Department:Química Analítica i Química Orgànica
Education area(s):Química en anglès
Entity:Universitat Rovira i Virgili (URV)
Creation date in repository:2021-07-28
Work's public defense date:2021-06-29
Academic year:2020-2021
Confidenciality:No
Subject areas:Chemistry
Access rights:info:eu-repo/semantics/openAccess
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