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TITLE:
Effects of common drugs on diamine oxidase enzyme activity and the correlation between histaminosis and gastrointestinal symptoms in humans - TFG:4153
Handle: https://hdl.handle.net/20.500.11797/TFG4153

Student:Puig Vera, Paula
Language:Anglès
Title in original language:Effects of common drugs on diamine oxidase enzyme activity and the correlation between histaminosis and gastrointestinal symptoms in humans
Title in different languages:Effects of common drugs on diamine oxidase enzyme activity and the correlation between histaminosis and gastrointestinal symptoms in humans
Keywords:Histamine intolerance, DAO deficiency, DAO-inhibiting drugs
Subject:Bioquímica i tecnologia
Abstract:Digestive enzymes play a key role in the digestive system, which can be affected by environmental conditions. There are food intolerances, with intolerance to biogenic amines being common. In humans, histamine can be degraded by histamine-N-methyltransferase or by diamine oxidase, which is found in the intestinal mucosa and degrades exogenous histamine. Its malfunction leads to histamine intolerance and the appearance of undesirable symptoms. The study shows the reversible effect of certain drugs on the enzyme, through interactions with its active site, and discusses the relationship between nowadays common gastrointestinal symptoms and the importance of diagnosing and treating patients.
Project director:Terra Barbadora, Ximena
Department:Bioquímica i Biotecnologia
Education area(s):Bioquímica i Biologia Molecular
Entity:Universitat Rovira i Virgili (URV)
Creation date in repository:2021-10-13
Work's public defense date:2021-06-29
Academic year:2020-2021
Confidenciality:No
Subject areas:Biochemistry and Technology
Access rights:info:eu-repo/semantics/openAccess
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