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TITLE:
The effect of succinate-SUCNR1 axis in Nonalcoholic Fatty Liver Disease: A study in a macrophage-specific SUCNR1 knock out model - TFG:4467
Handle: https://hdl.handle.net/20.500.11797/TFG4467

Student:El Hammouchi, Ahlam Oulad Ali
Language:en
Title in original language:The effect of succinate-SUCNR1 axis in Nonalcoholic Fatty Liver Disease: A study in a macrophage-specific SUCNR1 knock out model
Title in different languages:The effect of succinate-SUCNR1 axis in Nonalcoholic Fatty Liver Disease: A study in a macrophage-specific SUCNR1 knock out model
Keywords:SUCNR1, NAFLD, macrophage
Subject:Bioquímica i biotecnologia
Abstract:The pathogenesis of nonalcoholic fatty liver disease (NAFLD) is triggered through multiple causes (high-fat diet, sedentary life, insulin resistance), some of them unknown. Succinate has been observed to trigger hepatic fibrogenesis through SUCNR1 signaling, but its effects on other NAFLD-associated phenomena – fibrosis and inflammation – is not yet fully described. A study from IISPV found succinate to activate an anti-inflammatory program in macrophages. In this sense, succinate-SUCNR1 could be involved in hepatic inflammation in NAFLD. This hypothesis was addressed through evaluation of inflammation, ER stress, autophagy and metabolism alterations in SUCNR1 knock-out NAFLD mice, concluding with evidence that SUCNR1 deficiency does not affect NAFLD development.
Project director:Serena Perelló, Carolina
Department:Bioquímica i Biotecnologia
Education area(s):Bioquímica i Biologia Molecular
Entity:Universitat Rovira i Virgili (URV)
Creation date in repository:2022-03-01
Work's public defense date:2021-06-29
Academic year:2020-2021
Confidenciality:No
Subject areas:Biochemistry and biotechnology
Access rights:info:eu-repo/semantics/openAccess
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