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TITLE:
A decrease in liver carnitine concentration has an unfavorable effect on NAFLD - TFG:4649
Handle: https://hdl.handle.net/20.500.11797/TFG4649

Student:Pinto Caparrós, Laura
Language:en
Title in original language:A decrease in liver carnitine concentration has an unfavorable effect on NAFLD
Title in different languages:A decrease in liver carnitine concentration has an unfavorable effect on NAFLD
Keywords:NASH, carnitine, liver
Subject:Bioquímica i biotecnologia
Abstract:Background: NAFLD starts with simple inflammation up to a more severe form such as non-alcoholic steatohepatitis (NASH), in which other clinical signs are found with mitochondrial dysfunction. Carnitines, have been linked to the progression of NAFLD as well as the degree of NASH. Objectives: We investigated the difference patients with NASH and without NASH by measuring carnitine concentrations in plasma and liver. Results: Comparison of carnitine concentrations in liver of NASH patients with Non-NASH patients revealed that carnitine concentrations were found to be decreased in NASH. Conclusions: Beta-oxidation, mitochondrial mitophagy and apoptosis appear to be altered as the disease progresses.
Project director:Beltrán Debón, Raúl
Department:Bioquímica i Biotecnologia
Education area(s):Bioquímica i Biologia Molecular
Entity:Universitat Rovira i Virgili (URV)
Creation date in repository:2022-06-17
Work's public defense date:2021-06-28
Academic year:2020-2021
Confidenciality:No
Subject areas:Biochemistry and biotechnology
Access rights:info:eu-repo/semantics/openAccess
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