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TITLE:
Identification of new interaction partners for Aquaporin 4 in S. cerevisiae using BiFC and FACS - TFG:5019
Handle: https://hdl.handle.net/20.500.11797/TFG5019

Student:Delgado Gil, Raquel
Language:en
Title in original language:Identification of new interaction partners for Aquaporin 4 in S. cerevisiae using BiFC and FACS
Title in different languages:Identification of new interaction partners for Aquaporin 4 in S. cerevisiae using BiFC and FACS
Keywords:Aquaporin 4 (AQP4), Bimolecular Fluorescence Complementation (BiFC), Fluorescence-Activated Cell Sorting (FACS)
Subject:Biotecnologia
Abstract:Aquaporin 4 (AQP4) is strongly important for water transport in the human brain. In healthy conditions, it is polarized in perivascular astrocyte end foot membranes. However, interactions with certain proteins may affect that polarization, leading to neuropathological conditions. In this project, new interaction partners of AQP4 are searched for in a human brain cDNA library using Saccharomyces cerevisiae as host by coupling Bimolecular Fluorescence Complementation and Fluorescence-Activated Cell Sorting. Positive results have been obtained that may relate to an unknown protein interacting with AQP4 in the brain. Further analysis must be carried out to elucidate the nature of that interaction.
Project director:Cordero Otero, Ricardo Roman
Department:Bioquímica i Biotecnologia
Education area(s):Biotecnologia
Entity:Universitat Rovira i Virgili (URV)
TFG credits:9
Creation date in repository:2022-07-22
Work's public defense date:2022-06-22
Academic year:2021-2022
Confidenciality:No
Subject areas:Biochemistry and biotechnology
Access rights:info:eu-repo/semantics/openAccess
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