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TITLE:
Zonulin-1 as a potential biomarker for detection of immunological nonresponders among HIV infected patients - TFG:5142
Handle: https://hdl.handle.net/20.500.11797/TFG5142

Student:Ruiz Isant, Oriol
Language:en
Title in original language:Zonulin-1 as a potential biomarker for detection of immunological nonresponders among HIV infected patients
Title in different languages:Zonulin-1 as a potential biomarker for detection of immunological nonresponders among HIV infected patients
Keywords:Human Immunodeficiency Virus (HIV), Immunological nonresponders (INRs), zonulin
Subject:VIH (Virus)
Abstract:Human Immunodeficiency Virus (HIV) infection is still a major global health issue. Immunological nonresponders (INRs), which take up about 30% of HIV patients, do not fully recover CD4+ T-cell levels to optimal values upon administration of antiretroviral therapy. Since the gastrointestinal tract is largely affected due to HIV infection, potential biomarkers of gut damage have been studied. Zonulin, the only known modulator of tight junctions, was used in this project to discriminate between INRs, immunological responders and controls in subjects starting first antiretroviral therapy. Zonulin levels of INRs turned out to be significantly lower than controls (p < 0.01), indicating an important dysregulation of intestinal mucosal barrier function in INRs, and also leaving zonulin as a potential biomarker in the detection of INRs.
Project director:Rull Aixa, Anna
Department:Bioquímica i Biotecnologia
Education area(s):Bioquímica i Biologia Molecular
Entity:Universitat Rovira i Virgili (URV)
Creation date in repository:2022-07-28
Work's public defense date:2022-06-21
Academic year:2021-2022
Confidenciality:No
Access rights:info:eu-repo/semantics/openAccess
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