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TITLE:
Search for compounds with anti-melanogenesis activity from natural sources - TFG:6013
Handle: https://hdl.handle.net/20.500.11797/TFG6013

Student:Solé Vallés, Paula
Language:en
Title in original language:Search for compounds with anti-melanogenesis activity from natural sources
Title in different languages:Search for compounds with anti-melanogenesis activity from natural sources
Keywords:melanogenesis, natural compounds, tyrosinase.
Subject:Melanoma
Abstract:Melanogenesis is the complex multistep process of melanin synthesis that takes place in melanocytes. Although melanin has important functions in the human body, an abnormal accumulation causes hyperpigmentation skin disorders, and it is correlated with a higher risk of melanoma and neurodegenerative diseases. This study aimed to perform a screening of natural compounds with potential anti-melanogenesis activity. 4 compounds were tested using a tyrosinase inhibition assay and a quantification of melanin on B16F10 cells. The mechanism of action was evaluated by Western Blot. One of the 4 compounds displayed promising results on all the assays performed.
Project director:Calvo Manso, Enrique
Department:Bioquímica i Biotecnologia
Education area(s):Bioquímica i Biologia Molecular
Entity:Universitat Rovira i Virgili (URV)
Creation date in repository:2023-07-17
Work's public defense date:2022-06-21
Academic year:2021-2022
Confidenciality:Si
Subject areas:Biochemistry and biotechnology
Access rights:info:eu-repo/semantics/openAccess
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