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TITLE:
Study of Fn14 expression in semen cellular residue of prostate cancer patients - TFG:6034
Handle: https://hdl.handle.net/20.500.11797/TFG6034

Student:Soria Márquez, Andrea
Language:en
Title in original language:Study of Fn14 expression in semen cellular residue of prostate cancer patients
Title in different languages:Study of Fn14 expression in semen cellular residue of prostate cancer patients
Keywords:prostate cancer, semen cellular sediment, Fn14
Subject:Càncer
Abstract:Objective: To evaluate the ability to differentiate aggressive from indolent PCa using Fn14 gene mRNA expression obtained from the semen cell sediment of PCa patients (N=48) and 19 healthy control patients. Results: Serum PSA levels and Fn14 mRNA levels in seminal cell sediment were significantly higher in high-risk patients than in low-risk patients. ROC curve and logistic regression analysis showed that the biomarker panel composed of PSA and Fn14/TGM4 allowed distinguishing the aggressiveness of PCa. Conclusions: The non-invasive biomarker panel composed of serum PSA levels and Fn14/TGM4 mRNA levels in seminal cell sediment could be used to PCa aggressiveness prognose.
Project director:Guaita Esteruelas, Sandra; Rodríguez Chacón, Matilde
Department:Bioquímica i Biotecnologia
Education area(s):Bioquímica i Biologia Molecular
Entity:Universitat Rovira i Virgili (URV)
Creation date in repository:2023-07-17
Work's public defense date:2022-06
Academic year:2021-2022
Confidenciality:Si
Subject areas:Biochemistry and biotechnology
Access rights:info:eu-repo/semantics/openAccess
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