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TITLE:
The role of liver kinase B1 (LKB1) in the cell’s response to exogenous NAD+ - TFG:6095
Handle: https://hdl.handle.net/20.500.11797/TFG6095

Student:Adelantado Rubio, Alba
Language:en
Title in original language:The role of liver kinase B1 (LKB1) in the cell’s response to exogenous NAD+
Title in different languages:The role of liver kinase B1 (LKB1) in the cell’s response to exogenous NAD+
Keywords:LKB1 (liver kinase B1), AMPK (AMP-activated protein kinase), càncer
Subject:Quinases
Abstract:Cancer cells reprogram their metabolism to sustain dysregulated proliferation. LKB1 is an intracellular serine-threonine kinase with important roles in metabolism and proliferation. Almost 5% of all cancers show altered expression in LKB1. NAD+ has an important role in energy homeostasis. NAD+ and its precursors have been explored as potential cancer therapeutics. In this project, the role of LKB1 in response to NAD+ in U2OS and HeLa cells has been studied. The results showed that LKB1 is necessary for optimal cell proliferation in U2OS cells and that LKB1 is not the only factor dictating cellular response to exogenous NAD+.
Project director:Maya-Mendoza Apolinar; Arola Ferrer, Lluís Maria
Department:Bioquímica i Biotecnologia
Education area(s):Bioquímica i Biologia Molecular
Entity:Universitat Rovira i Virgili (URV)
Creation date in repository:2023-07-24
Work's public defense date:2022-06-22
Academic year:2020-2021
Confidenciality:Si
Subject areas:Biochemistry and biotechnology
Access rights:info:eu-repo/semantics/openAccess
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