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TITLE:
Study of cell adhesion in dyskerin silencing - TFG:6110
Handle: https://hdl.handle.net/20.500.11797/TFG6110

Student:González Rodríguez, Mirando
Language:en
Title in original language:Study of cell adhesion in dyskerin silencing
Title in different languages:Study of cell adhesion in dyskerin silencing
Keywords:dyskerin, focal adhesions, DKC1
Subject:Càncer
Abstract:Cell adhesion is essential for cell communication and control, as well as tissue formation and maintenance. The behavior and function of cells can be influenced and controlled by mechanical interactions between a cell and the ECM, interactions known as focal adhesions. Dyskerin is a protein whose overexpression has been related to spontaneous onset of cancer and whose deficiency is associated with a disorder, dyskeratosis congenita, and cytoskeleton remodeling. To further study the effects of dyskerin in cell adhesion, DKC1 (the gene that codes for dyskerin) was silenced in cells. Immunofluorescence analysis revealed that dyskerin deficiency results in alteration of FAs.
Project director:Suárez Recio, Manuel; Turano, Mimmo
Department:Bioquímica i Biotecnologia
Education area(s):Bioquímica i Biologia Molecular
Entity:Universitat Rovira i Virgili (URV)
Creation date in repository:2023-07-24
Work's public defense date:2022-06-22
Academic year:2021-2022
Confidenciality:Si
Subject areas:Biochemistry and biotechnology
Access rights:info:eu-repo/semantics/openAccess
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