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TITLE:
Beyond single mutations: exploring simultaneous mutations in sars-cov-2 m-pro and spike proteins - TFG:6582
Handle: https://hdl.handle.net/20.500.11797/TFG6582

Student:Puscasu, Alberto Constantino
Language:en
Title in original language:Beyond single mutations: exploring simultaneous mutations in sars-cov-2 m-pro and spike proteins
Keywords:Sars-cov-2, simultaneous mitations
Subject:COVID-19 (Malaltia)
Abstract:We examined a dataset comprising 922,474 mutations in the M-pro protein and 44,278,219 mutations in the Spike protein of SARS-CoV-2 aiming to find simultaneous mutations on those proteins and trying to understand their biological reason. Both the M-pro and Spike proteins have simultaneous mutations. We discovered that these simultaneous mutations are not directly implied in maintaining the structure of the protein or the secondary RNA structure of SARS-CoV-2.This study sheds light on the significance of simultaneous mutations and their relationship with Variants of Concern (VOCs). Simultaneous mutations in the Spike have been related to the signature mutations of different VOCs.
Project director:García vallvé, santiago
Department:Bioquímica i Biotecnologia
Education area(s):Bioquímica i Biologia Molecular
Entity:Universitat Rovira i Virgili (URV)
Creation date in repository:2023-12-18
Work's public defense date:2023-06-21
Academic year:2022-2023
Confidenciality:No
Subject areas:Biochemistry and biotechnology
Access rights:info:eu-repo/semantics/openAccess
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