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TITLE:
Unveiling the role of oxidized myelin debris in BV-2 microglia: Insights into multiple sclerosis - TFG:6586
Handle: https://hdl.handle.net/20.500.11797/TFG6586

Student:Santacreu Vilaseca, Marta
Language:en
Title in original language:Unveiling the role of oxidized myelin debris in BV-2 microglia: Insights into multiple sclerosis
Keywords:Multiple Sclerosis, Microglia, Oxidized Myelin
Subject:Esclerosi múltiple
Abstract:Multiple sclerosis is an autoimmune inflammatory neurodegenerative disease characterized by an immune attack on the myelin sheath, leading to an inflammatory environment with increased reactive oxygen species and myelin debris generation that must be cleared by microglia cells. Phagocytosis of oxidized myelin debris by microglia was examined using BV-2 cells. The impact on cell viability, protein synthesis, and inflammatory cytokine expression was assessed. Phagocytic activity was analyzed through CFSE staining of the myelin. Results reveal disparities in antioxidant and cellular metabolism proteins. Significant differences in phagosomal degradation were finded suggesting that oxidized myelin disrupts microglial functions and activity.
Project director:Mas Capdevila, Anna
Department:Bioquímica i Biotecnologia
Education area(s):Bioquímica i Biologia Molecular
Entity:Universitat Rovira i Virgili (URV)
Creation date in repository:2023-12-18
Work's public defense date:2023-06-22
Academic year:2022-2023
Confidenciality:No
Subject areas:Biochemistry and biotechnology
Access rights:info:eu-repo/semantics/openAccess
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