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TITLE:
Role of the nuclear receptor RORγ1 in the differentiation and function of brown adipocytes - TFG:6587
Handle: https://hdl.handle.net/20.500.11797/TFG6587

Student:Angrill Navarro, Aleix
Language:en
Title in original language:Role of the nuclear receptor RORγ1 in the differentiation and function of brown adipocytes
Keywords:RORγ1, brown adipocytes, differentiation
Subject:Biotecnologia
Abstract:Retinoic acid-related orphan receptor gamma 1 (RORγ1) is drawing interest as a therapeutic target for the treatment of obesity and diabetes. Preliminary results showed that RORγ1 is highly expressed in brown adipose tissue (BAT) and increases during differentiation of immortalized brown adipocytes (iBA). To elucidate its role in BAT, we silenced RORγ1 expression using small interfering RNAs and inhibited RORγ1 activity by RORγ inverse agonists in iBA preadipocytes. Although we did not obtain firm results regarding morphological differentiation changes and brown fat markers expression, we validated iBA preadipocytes transfection.
Project director:Arola Ferrer, Luis Maria
Department:Bioquímica i Biotecnologia
Education area(s):Bioquímica i Biologia Molecular
Entity:Universitat Rovira i Virgili (URV)
Creation date in repository:2023-12-18
Work's public defense date:2023-06-21
Academic year:2022-2023
Confidenciality:No
Subject areas:Biochemistry and biotechnology
Access rights:info:eu-repo/semantics/openAccess
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