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TITLE:
Biomarcadores de Parkinson en humor acuoso y regulación de la microglía en la neuroinflamación - TFG:6604

Student:González Subías, Marc
Language:spa
Title in original language:Biomarcadores de Parkinson en humor acuoso y regulación de la microglía en la neuroinflamación
Title in different languages:Parkinson's biomarkers in aqueous humor and regulation of microglia in neuroinflammation.
Keywords:Transcriptomics, Metabolomics, Parkinson
Subject:Parkinson, Malaltia de
Abstract:In this work, a metabolomic analysis of aqueous humor samples is carried out using mass spectrometry. The data obtained show various metabolic pathways involved in neuroinflammation of neuronal tissue, such as glutathione and arginine metabolism. One approach is to decrease microglia-orchestrated neuroinflammation, for example, through treatment with A2AR antagonists and CB2R agonists. The transcriptomic effects that these compounds had on inflamed microglia were studied. The results were relevant in the reversal of microglial activation from one state (M1) to one (M2).
Project director:Martínez Micaelo, Nieves Beatriz
Department:Bioquímica i Biotecnologia
Education area(s):Bioquímica i Biologia Molecular
Entity:Universitat Rovira i Virgili (URV)
Creation date in repository:2023-12-20
Work's public defense date:2023-06-21
Academic year:2022-2023
Confidenciality:No
Subject areas:Biochemistry and biotechnology
Access rights:info:eu-repo/semantics/openAccess
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