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TITLE:
Virtual screening for novel anticancer agents targeting the PDZ2 domain of syntenin-1 - TFG:6610
Handle: https://hdl.handle.net/20.500.11797/TFG6610

Student:Arasa Estivill, Guillem
Language:en
Title in original language:Virtual screening for novel anticancer agents targeting the PDZ2 domain of syntenin-1
Keywords:mda-9, PDZ2, molecular docking
Subject:Càncer
Abstract:Syntenin-1 is an overexpressed protein in aggressive versions of certain cancers. It has been observed that its inhibition could decrease tumor proliferation. In this project, we used a virtual screening workflow in order to find potential inhibitory molecules that could bind to its PDZ2 domain binding site. We performed a molecular ligand docking of a large library of commercial compounds and developed a pharmacophore model based on the SYNTi ligand in order to filter the molecules that didn't have certain features required for a potent inhibition. This project resulted in a set of 6 molecules that could potentially inhibit syntenin-1 activity.
Project director:Pujadas Anguiano, Gerard
Department:Bioquímica i Biotecnologia
Education area(s):Biotecnologia
Entity:Universitat Rovira i Virgili (URV)
Creation date in repository:2024-01-09
Work's public defense date:2023-06-20
Academic year:2022-2023
Confidenciality:No
Subject areas:Biochemistry and biotechnology
Access rights:info:eu-repo/semantics/openAccess
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