Efectividad del tratamiento con triple terapia de fármacos moduladores de CFTR en pacientes con fibrosis quística con mutación f508del y/o de función mínima de gen CFTR: revisión sistemática y metaanálisis

Herrerías Dávila, Paula

Belongs to TFG:SerieGeneralMED collection

TITLE:

Efectividad del tratamiento con triple terapia de fármacos moduladores de CFTR en pacientes con fibrosis quística con mutación f508del y/o de función mínima de gen CFTR: revisión sistemática y metaanálisis - TFG:7689

Handle:

https://hdl.handle.net/20.500.11797/TFG7689

Student:	Herrerías Dávila, Paula
Language:	spa
Title in original language:	Efectividad del tratamiento con triple terapia de fármacos moduladores de CFTR en pacientes con fibrosis quística con mutación f508del y/o de función mínima de gen CFTR: revisión sistemática y metaanálisis
Title in different languages:	Effectiveness of treatment with triple therapy of CFTR modulating drugs in patients with cystic fibrosis with f508del mutation and/or minimal CFTR gene function: systematic review and meta-analysis
Keywords:	Cystic fibrosis, triple therapy, F508del.
Subject:	Medicina
Abstract:	Cystic fibrosis is an autosomal recessive genetic disease characterized by persistent lung infections, pancreatic insufficiency and high levels of chloride in sweat, caused by mutations in the CFTR protein, the most common being F508del. Treatments include antibiotics, physical therapy, and CFTR modulators. This study evaluated the effectiveness of triple therapy with CFTR modulators in patients ≥ 6 years of age with F508del and/or minimal function mutations. 8 clinical trials with 1243 participants were analyzed, showing significant improvements in lung function (ppFEV1), sweat chloride and the CFQ-R questionnaire. Triple therapy proved to be superior.
Project director:	Escribano Subías, Joaquín
Department:	Medicina i Cirurgia
Education area(s):	Medicina
Entity:	Universitat Rovira i Virgili (URV)
TFG credits:	6
Creation date in repository:	2024-01-10
Work's public defense date:	2024-13-06
Academic year:	2023-2024
Confidenciality:	No
Access rights:	info:eu-repo/semantics/openAccess

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Coverage:	No
Type:	info:eu-repo/semantics/bachelorThesis
Contributor:	Escribano Subías, Joaquín
Títol:	Efectividad del tratamiento con triple terapia de fármacos moduladores de CFTR en pacientes con fibrosis quística con mutación f508del y/o de función mínima de gen CFTR: revisión sistemática y metaanálisis
Language:	spa
Subject:	Ciències de la salut Medicina
Format:	Universitat Rovira i Virgili (URV)
Creator:	Herrerías Dávila, Paula
Rights:	info:eu-repo/semantics/openAccess
Date:	2024-13-06

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