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TITLE:

Influence of adenylate cyclase in Pleiotropic Drug Resistance Transporter Genes expression after azole exposure and ergosterol content of Rhizopus microsporus - TFG:7946
Handle:

https://hdl.handle.net/20.500.11797/TFG7946

Student:Béjar González, Sonia
Language:en
Title in original language:Influence of adenylate cyclase in Pleiotropic Drug Resistance Transporter Genes expression after azole exposure and ergosterol content of Rhizopus microsporus
Title in different languages:Influence of adenylate cyclase in Pleiotropic Drug Resistance Transporter Genes expression after azole exposure and ergosterol content of Rhizopus microsporus
Keywords:Rhizopus microsporus, adenylate cyclase, Pleiotropic Drug Resistance Transporter Genes
Subject:Bioquímica i Biologia Molecular
Abstract:Mucormycosis, mainly caused by the fungus Rhizopus microsporus, is an opportunistic infection often resistant to azole antifungals. A major acquired resistance mechanism is the upregulation of Pleiotropic Drug Resistance Transporter Genes (pdr), which encode efflux pumps that expel drugs from cells. In other fungi, this mechanism and resistance to azoles have been linked to adenylate cyclase and fungal ergosterol content. This work revealed higher ergosterol amounts in an R. microsporus strain lacking adenylate cyclase without affecting azole susceptibility, along with better adaptation to high itraconazole concentrations and a tendency to upregulate pdr genes expression when exposed to posaconazole and itraconazole.
Project director:Rodríguez Calvo, Ricardo
Work's codirector:Capilla Luque, Javier; Sanchis Talón, Marta
Department:Ciències Mèdiques Bàsiques
Education area(s):Bioquímica i Biologia Molecular
Entity:Universitat Rovira i Virgili (URV)
Creation date in repository:2025-01-22
Work's public defense date:2024-09-13
Academic year:2023-2024
Confidenciality:No
Subject areas:Biochemistry and biotechnology
Access rights:info:eu-repo/semantics/openAccess
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