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TITLE:
Stereoselective synthesis of cyclopropenone-based ceramide derivatives as potential dihydroceramide desaturase 1 inhibitors - TFM:1328
Handle: https://hdl.handle.net/20.500.11797/TFM1328

Student:Figueras Boldó, Adrià
Language:en
Title in original language:Stereoselective synthesis of cyclopropenone-based ceramide derivatives as potential dihydroceramide desaturase 1 inhibitors
Title in different languages:Stereoselective synthesis of cyclopropenone-based ceramide derivatives as potential dihydroceramide desaturase 1 inhibitors
Keywords:stereoselective synthesis, cyclopropenone, dihydroceramide desaturase 1 (Des1)
Subject:química
Abstract:The stereoselective synthesis of cyclopropenone-based ceramide derivatives as potential Des 1 inhibitors is presented. By harnessing the singular reactivity of cyclopropenones one of the potential Des1 inhibitors, bearing a 1,2-dichalcogen heterocycle, has been synthesized in an effective and time-saving manner via late-stage functionalization. Docking studies support their potential as Des1 inhibitors. Both synthetized compounds will be evaluated as Des1 inhibitors
Project director:Matheu Malpartida, Maria Isabel
Department:Química Analítica i Química Orgànica
Education area(s):Síntesi, Catàlisi i Disseny Molecular
Entity:Universitat Rovira i Virgili (URV)
Work's public defense date:2022-07-21
Academic year:2021-2022
Confidenciality:No
Subject areas:Chemistry
APS:NO
Creation date in repository:2023-05-22
Access Rights:info:eu-repo/semantics/openAccess
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