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TITLE:
Neuroinflammation, microglia, NAD+, type 1 diabetes mellitus, vitamin B3 - TFM:1413

Student:Torres Mendez, Jeimy Katherine
Language:en
Title in original language:Neuroinflammation, microglia, NAD+, type 1 diabetes mellitus, vitamin B3
Title in different languages:Neuroinflammation, microglia, NAD+, type 1 diabetes mellitus, vitamin B3
Keywords:neuroinflammation, NAD+, type 1 diabetes mellitus
Subject:Nicotina
Abstract:Diabetes mellitus is frequently linked to chronic neuroinflammation. Accumulating evidence suggest that activated microglia underlies diabetic neuropathy. Currently there are no specific treatments for diabetic neuropathy. NAD+ is a mandatory coenzyme for the action of several NAD+ consuming enzymes that are involved in the inflammatory response. Therefore, its replenishment was considered as a potential therapy to prevent neuroinflammation. In this context, nicotinamide (NAM), which is a precursor of NAD+, may have positive effects on diabetic neuroinflammation. We tested the hypothesis that increased bioavailability of NAM will attenuate activation of microglia in a mouse model of experimental diabetes mellitus type 1 (T1D)
Department:Bioquímica i Biotecnologia
Education area(s):Nutrició i Metabolisme
Entity:Universitat Rovira i Virgili (URV)
Work's public defense date:2022-06-20
Academic year:2021-2022
Confidenciality:Si
Subject areas:Health sciences
APS:NO
Creation date in repository:2023-07-05
Access Rights:info:eu-repo/semantics/openAccess
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