Repositori institucional URV
| URV's Author/s: | Salas Salvadó, Jorge |
| Author, as appears in the article.: | Smith C.E., Coltell O., Sorlí J.V., Estruch R., Martínez-González M.Á., Salas-Salvadó J., Fitó M., Arós F., Dashti H.S., Lai C.Q., Miró L., Serra-Majem L., Gómez-Gracia E., Fiol M., Ros E., Aslibekyan S., Hidalgo B., Neuhouser M.L., Di C., Tucker K.L., Arnett D.K., Ordovás J.M., Corella D. |
| Author's mail: | jordi.salas@urv.cat |
| Author identifier: | 0000-0003-2700-7459 |
| Journal publication year: | 2016 |
| Publication Type: | Journal Publications |
| ISSN: | 20452322 |
| APA: | Smith C.E., Coltell O., Sorlí J.V., Estruch R., Martínez-González M.Á., Salas-Salvadó J., Fitó M., Arós F., Dashti H.S., Lai C.Q., Miró L., Serra-Maje (2016). Associations of the MCM6-rs3754686 proxy for milk intake in Mediterranean and American populations with cardiovascular biomarkers, disease and mortality: Mendelian randomization. Scientific Reports, 6(33188), 33188-. DOI: 10.1038/srep33188 |
| Papper original source: | Scientific Reports. 6 (33188): 33188- |
| Abstract: | Controversy persists on the association between dairy products, especially milk, and cardiovascular diseases (CVD). Genetic proxies may improve dairy intake estimations, and clarify diet-disease relationships through Mendelian randomization. We meta-analytically (n???20,089) evaluated associations between a lactase persistence (LP) SNP, the minichromosome maintenance complex component 6 (MCM6)-rs3754686C>T (nonpersistence>persistence), dairy intake, and CVD biomarkers in American (Hispanics, African-American and Whites) and Mediterranean populations. Moreover, we analyzed longitudinal associations with milk, CVD and mortality in PREDIMED), a randomized Mediterranean diet (MedDiet) intervention trial (n?=?7185). The MCM6-rs3754686/MCM6-rs309180 (as proxy), LP-allele (T) was strongly associated with higher milk intake, but inconsistently associated with glucose and lipids, and not associated with CVD or total mortality in the whole population. Heterogeneity analyses suggested some sex-specific associations. The T-allele was associated with higher CVD and mortality risk in women but not in men (P-sex interaction:0.005 and 0.032, respectively), mainly in the MedDiet group. However, milk intake was not associated with CVD biomarkers, CVD or mortality either generally or in sub-groups. Although MCM6-rs3754686 is a good milk intake proxy in these populations, attributing its associations with CVD and mortality in Mediterranean women to milk is unwarranted, as other factors limiting the assumption of causality in Mendelian randomization may exist. |
| Article's DOI: | 10.1038/srep33188 |
| Link to the original source: | https://www.nature.com/articles/srep33188 |
| Papper version: | info:eu-repo/semantics/publishedVersion |
| licence for use: | https://creativecommons.org/licenses/by/3.0/es/ |
| Department: | Bioquímica i Biotecnologia |
| Licence document URL: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
| Thematic Areas: | Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física |
| Keywords: | Mortality Mcm6-rs3754686 Cardiovascular biomarkers |
| Entity: | Universitat Rovira i Virgili |
| Record's date: | 2024-09-07 |
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