Association study of monoamine oxidase-A gene promoter polymorphism (MAOA-uVNTR) with self-reported anxiety and other psychopathological symptoms in a community sample of early adolescents - imarina:3642034
Voltas, Nuria; Aparicio, Estefania; Arija, Victoria; Canals, Josefa (2015). Association study of monoamine oxidase-A gene promoter polymorphism (MAOA-uVNTR) with self-reported anxiety and other psychopathological symptoms in a community sample of early adolescents. Journal Of Anxiety Disorders, 31(), 65-72. DOI: 10.1016/j.janxdis.2015.02.004
Paper original source:
Journal Of Anxiety Disorders. 31 65-72
Abstract:
The polymorphism upstream of the gene for monoamine oxidase A (MAOA-uVNTR) is reported to be an important enzyme involved in human physiology and behavior. With a sample of 228 early-adolescents from a community sample (143 girls) and adjusting for environmental variables, we examined the influence of MAOA-uVNTR alleles on the scores obtained in the Screen for Childhood Anxiety and Related Emotional Disorders and in the Child Symptom Inventory-4. Our results showed that girls with the high-activity MAOA allele had higher scores for generalized and total anxiety than their low-activity peers, whereas boys with the low-activity allele had higher social phobia scores than boys with the high-activity allele. Results for conduct disorder symptoms did not show a significant relationship between the MAOA alleles and the presence of these symptoms. Our findings support a possible association, depending on gender, between the MAOA-uVNTR polymorphism and psychopathological disorders such as anxiety, which affects high rates of children and adolescents.
The polymorphism upstream of the gene for monoamine oxidase A (MAOA-uVNTR) is reported to be an important enzyme involved in human physiology and behavior. With a sample of 228 early-adolescents from a community sample (143 girls) and adjusting for environmental variables, we examined the influence of MAOA-uVNTR alleles on the scores obtained in the Screen for Childhood Anxiety and Related Emotional Disorders and in the Child Symptom Inventory-4. Our results showed that girls with the high-activity MAOA allele had higher scores for generalized and total anxiety than their low-activity peers, whereas boys with the low-activity allele had higher social phobia scores than boys with the high-activity allele. Results for conduct disorder symptoms did not show a significant relationship between the MAOA alleles and the presence of these symptoms. Our findings support a possible association, depending on gender, between the MAOA-uVNTR polymorphism and psychopathological disorders such as anxiety, which affects high rates of children and adolescents.
Title:
Association study of monoamine oxidase-A gene promoter polymorphism (MAOA-uVNTR) with self-reported anxiety and other psychopathological symptoms in a community sample of early adolescents
Type:
Journal Publications
Contributor:
Universitat Rovira i Virgili
Subject:
Clinical Psychology,Psychiatry,Psychiatry and Mental Health,Psychology, Clinical Self report Psychopathology Promoter regions, genetic Polymorphism, genetic Phobic disorders Personality inventory Monoamine oxidase Minisatellite repeats Maoa-uvntr Male Longitudinal studies Life change events Humans Genotype Gender Female Depressive disorder Anxiety disorders Anxiety Alleles Adolescents Adolescent maoa-uvntr gender anxiety adolescents Saúde coletiva Psychology, clinical Psychology Psychiatry and mental health Psychiatry Psicología Nutrição Medicina ii Medicina i General medicine Educação física Clinical psychology Ciencias sociales Ciências biológicas ii