Repositori institucional URV
| URV's Author/s: | Salas Salvadó, Jorge |
| Author, as appears in the article.: | Yu E; Papandreou C; Ruiz-Canela M; Guasch-Ferre M; Clish CB; Dennis C; Liang L; Corella D; Fitó M; Razquin C; Lapetra J; Estruch R; Ros E; Cofán M; Arós F; Toledo E; Serra-Majem L; Sorlí JV; Hu FB; Martinez-Gonzalez MA; Salas-Salvado J |
| Author's mail: | jordi.salas@urv.cat |
| Author identifier: | 0000-0003-2700-7459 |
| Journal publication year: | 2018 |
| Publication Type: | Journal Publications |
| ISSN: | 00099147 |
| APA: | Yu E; Papandreou C; Ruiz-Canela M; Guasch-Ferre M; Clish CB; Dennis C; Liang L; Corella D; Fitó M; Razquin C; Lapetra J; Estruch R; Ros E; Cofán M; Ar (2018). Association of tryptophan metabolites with incident type 2 diabetes in the PREDIMED trial: A case–cohort study. Clinical Chemistry, 64(8), 1211-1220. DOI: 10.1373/clinchem.2018.288720 |
| Papper original source: | Clinical Chemistry. 64 (8): 1211-1220 |
| Abstract: | © 2018 American Association for Clinical Chemistry. BACKGROUND: Metabolites of the tryptophan– kynurenine pathway (i.e., tryptophan, kynurenine, kynurenic acid, quinolinic acid, 3-hydroxyanthranilic) may be associated with diabetes development. Using a case– cohort design nested in the Prevención con Dieta Mediterránea (PREDIMED) study, we studied the associations of baseline and 1-year changes of these metabolites with incident type 2 diabetes (T2D). METHODS: Plasma metabolite concentrations were quantified via LC-MS for n 641 in a randomly selected subcohort and 251 incident cases diagnosed during 3.8 years of median follow-up. Weighted Cox models adjusted for age, sex, body mass index, and other T2D risk factors were used. RESULTS: Baseline tryptophan was associated with higher risk of incident T2D (hazard ratio 1.29; 95% CI, 1.04 –1.61 per SD). Positive changes in quinolinic acid from baseline to 1 year were associated with a higher risk of T2D (hazard ratio 1.39; 95% CI, 1.09 –1.77 per SD). Baseline tryptophan and kynurenic acid were directly associated with changes in homeostatic model assessment for insulin resistance (HOMA-IR) from baseline to 1 year. Concurrent changes in kynurenine, quinolinic acid, 3-hydroxyanthranilic acid, and kynurenine/tryptophan ratio were associated with baseline-to-1-year changes in HOMA-IR. CONCLUSIONS: Baseline tryptophan and 1-year increases in quinolinic acid were positively associated with incident T2D. Baseline and 1-year changes in tryptophan metabolites predicted changes in HOMA-IR. Tryptophan levels may initially increase and then deplete as diabetes progresses in severity. |
| Article's DOI: | 10.1373/clinchem.2018.288720 |
| Link to the original source: | https://academic.oup.com/clinchem/article/64/8/1211/5608820 |
| Papper version: | info:eu-repo/semantics/acceptedVersion |
| licence for use: | https://creativecommons.org/licenses/by/3.0/es/ |
| Department: | Bioquímica i Biotecnologia |
| Licence document URL: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
| Thematic Areas: | Odontología Medicine (miscellaneous) Medicine (all) Medicina iii Medicina ii Medicina i Medical laboratory technology General medicine Farmacia Clinical biochemistry Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Biochemistry (medical) |
| Keywords: | @infoAeu @residentesaeu @uroweb Etiqueta «#» Hashtag |
| Entity: | Universitat Rovira i Virgili |
| Record's date: | 2024-09-07 |
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