Repositori institucional URV
| URV's Author/s: | BASAURE GARCÍA, PÍA ISABEL / Cabré Bargalló, Maria / Colomina Fosch, Maria Teresa / Domingo Roig, José Luis / Guardia Escoté, Laia |
| Author, as appears in the article.: | Basaure P, Guardia-Escote L, Cabré M, Peris-Sampedro F, Sánchez-Santed F, Domingo JL, Colomina MT. |
| Author's mail: | maria.cabre@urv.cat joseluis.domingo@urv.cat mariateresa.colomina@urv.cat |
| Author identifier: | 0000-0003-4124-8603 0000-0001-6647-9470 0000-0002-5619-4874 |
| Journal publication year: | 2018 |
| Publication Type: | Journal Publications |
| ISSN: | 02786915 |
| APA: | Basaure P, Guardia-Escote L, Cabré M, Peris-Sampedro F, Sánchez-Santed F, Domingo JL, Colomina MT. (2018). Postnatal chlorpyrifos exposure and apolipoprotein E (APOE) genotype differentially affect cholinergic expression and developmental parameters in transgenic mice. Food And Chemical Toxicology, 118(), 42-52. DOI: 10.1016/j.fct.2018.04.065 |
| Papper original source: | Food And Chemical Toxicology. 118 42-52 |
| Abstract: | Chlorpyrifos (CPF) is one of the most commonly used organophosphate pesticides in the world. Our previous results described that apolipoprotein E (APOE) polymorphisms are a source of individual differences in susceptibility to CPF. The aim of this study was to assess the physical and biochemical effects of postnatal exposure to CPF in the apoE targeted replacement mouse model. Mice were exposed to CPF at 0 or 1 mg/kg/day from postnatal day 10-15. Physical development, plasma and forebrain cholinesterase (ChE) activity and gene expression in liver and forebrain were evaluated. CPF exposure delays physical maturation and decreases the expression of choline acetyltransferase, α4-subunit and the α7 receptor. CPF decreases the expression of vesicular acetylcholine transporter (VAChT) mRNA in the forebrain only in apoE3 mice. The expression of paraoxonase-2 in the forebrain was also influenced by APOE genotype and CPF. Differences between genotypes were observed in litter size, ChE activity, expression of butyrylcholinesterase and paraoxonase-1 in liver and variants of acetylcholinesterase, VAChT and the α7 receptor in the forebrain. These results support that there are different vulnerabilities to postnatal CPF exposure according to the APOE polymorphism, which in turn affects the cholinergic system and defenses to oxidative stress. |
| Article's DOI: | 10.1016/j.fct.2018.04.065 |
| Link to the original source: | https://www.sciencedirect.com/science/article/pii/S0278691518302898?via%3Dihub |
| Papper version: | info:eu-repo/semantics/acceptedVersion |
| licence for use: | https://creativecommons.org/licenses/by/3.0/es/ |
| Department: | Psicologia Ciències Mèdiques Bàsiques Bioquímica i Biotecnologia |
| Licence document URL: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
| Thematic Areas: | Toxicology Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física |
| Keywords: | Vesicular acetylcholine transport proteins Sex differences Prosencephalon Polymorphism, genetic Pesticide Paraoxonase Oxidative stress Mice, transgenic Mice, inbred c57bl Mice Male Litter size Insecticides Inactivation, metabolic Genotype Female Development Cholinergic system Choline o-acetyltransferase Chlorpyrifos Butyrylcholinesterase Aryldialkylphosphatase Apolipoprotein e4 Apolipoprotein e3 Apoe Animals, newborn Animals Alpha7 nicotinic acetylcholine receptor Acetylcholinesterase pesticide paraoxonase development cholinergic system apoe |
| Entity: | Universitat Rovira i Virgili |
| Record's date: | 2024-09-07 |
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