URV's Author/s: | Babio Sánchez, Nancy Elvira / Díaz López, Andres / Salas Salvadó, Jorge |
Author, as appears in the article.: | Konieczna, J; Yanez, A; Monino, M; Babio, N; Toledo, E; Martinez-Gonzalez, M A; Sorli, J, V; Salas-Salvado, J; Estruch, R; Ros, E; Alonso-Gomez, A; Schroder, H; Lapetra, J; Serra-Majem, Ll; Pinto, X; Gutierrez-Bedmar, M; Diaz-Lopez, A; Gonzalez, J, I; Fito, M; Forga, L; Fiol, M; Romaguera, D |
Author's mail: | andres.diaz@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat |
Author identifier: | 0000-0002-7500-5629 0000-0003-2700-7459 0000-0003-3527-5277 |
Journal publication year: | 2020 |
Publication Type: | Journal Publications |
ISSN: | 02615614 |
APA: | Konieczna, J; Yanez, A; Monino, M; Babio, N; Toledo, E; Martinez-Gonzalez, M A; Sorli, J, V; Salas-Salvado, J; Estruch, R; Ros, E; Alonso-Gomez, A; Sc (2020). Longitudinal changes in Mediterranean diet and transition between different obesity phenotypes. Clinical Nutrition, 39(3), 966-975. DOI: 10.1016/j.clnu.2019.04.002 |
Paper original source: | Clinical Nutrition. 39 (3): 966-975 |
Abstract: | © 2019 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism Background & aims: Little is known about the impact of specific dietary patterns on the development of obesity phenotypes. We aimed to determine the association of longitudinal changes in adherence to the traditional Mediterranean diet (MedDiet) with the transition between different obesity phenotypes. Methods: Data of 5801 older men and women at high cardiovascular risk from PREDIMED trial were used. Adherence to MedDiet was measured with the validated 14p-Mediterranean Diet Adherence Screener (MEDAS). Using the simultaneous combination of metabolic health- and body size-related parameters participants were categorized into one of four phenotypes: metabolically healthy and abnormal obese (MHO and MAO), metabolically healthy and abnormal non-obese (MHNO and MANO). Cox regression models with yearly repeated measures during 5-year of follow-up were built with use of Markov chain assumption. Results: Each 2-point increase in MEDAS was associated with the following transitions: in MAO participants, with a 16% (95% CI 3–31%) greater likelihood of becoming MHO; in MHO participants with a 14% (3–23%) lower risk of becoming MAO; in MHNO participants with a 18% (5–30%) lower risk of becoming MHO. In MANO women, but not in men, MEDAS was associated with 20% (5–38%) greater likely of becoming MHNO (p for interaction by gender 0.014). No other significant associations were observed. Conclusions: Better adherence to the traditional MedDiet is associated with transitions to healthier phenotypes, promoting metabolic health improvement in MAO, MANO (only in women), and MHO, as well as protecting against obesity incidence in MHNO subjects. |
Article's DOI: | 10.1016/j.clnu.2019.04.002 |
Link to the original source: | https://www.clinicalnutritionjournal.com/article/S0261-5614(19)30157-8/abstract |
Paper version: | info:eu-repo/semantics/acceptedVersion |
licence for use: | https://creativecommons.org/licenses/by/3.0/es/ |
Department: | Bioquímica i Biotecnologia Bioquímica i Biotecnologia |
Licence document URL: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
Thematic Areas: | Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Enfermagem Educação física Critical care and intensive care medicine Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología |
Keywords: | Transition probabilities The predimed trial Obesity phenotypes Metabolically healthy obese Metabolically abnormal non-obese Mediterranean diet the predimed trial obesity phenotypes metabolically healthy obese metabolically abnormal non-obese mediterranean diet |
Entity: | Universitat Rovira i Virgili |
Record's date: | 2025-02-19 |
Description: | © 2019 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism Background & aims: Little is known about the impact of specific dietary patterns on the development of obesity phenotypes. We aimed to determine the association of longitudinal changes in adherence to the traditional Mediterranean diet (MedDiet) with the transition between different obesity phenotypes. Methods: Data of 5801 older men and women at high cardiovascular risk from PREDIMED trial were used. Adherence to MedDiet was measured with the validated 14p-Mediterranean Diet Adherence Screener (MEDAS). Using the simultaneous combination of metabolic health- and body size-related parameters participants were categorized into one of four phenotypes: metabolically healthy and abnormal obese (MHO and MAO), metabolically healthy and abnormal non-obese (MHNO and MANO). Cox regression models with yearly repeated measures during 5-year of follow-up were built with use of Markov chain assumption. Results: Each 2-point increase in MEDAS was associated with the following transitions: in MAO participants, with a 16% (95% CI 3–31%) greater likelihood of becoming MHO; in MHO participants with a 14% (3–23%) lower risk of becoming MAO; in MHNO participants with a 18% (5–30%) lower risk of becoming MHO. In MANO women, but not in men, MEDAS was associated with 20% (5–38%) greater likely of becoming MHNO (p for interaction by gender 0.014). No other significant associations were observed. Conclusions: Better adherence to the traditional MedDiet is associated with transitions to healthier phenotypes, promoting metabolic health improvement in MAO, MANO (only in women), and MHO, as well as protecting against obesity incidence in MHNO subjects. |
Title: | Longitudinal changes in Mediterranean diet and transition between different obesity phenotypes |
Type: | Journal Publications |
Contributor: | Universitat Rovira i Virgili |
Subject: | Critical Care and Intensive Care Medicine,Nutrition & Dietetics,Nutrition and Dietetics Transition probabilities The predimed trial Obesity phenotypes Metabolically healthy obese Metabolically abnormal non-obese Mediterranean diet the predimed trial obesity phenotypes metabolically healthy obese metabolically abnormal non-obese mediterranean diet Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Enfermagem Educação física Critical care and intensive care medicine Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología |
Date: | 2020 |
Creator: | Konieczna, J Yanez, A Monino, M Babio, N Toledo, E Martinez-Gonzalez, M A Sorli, J, V Salas-Salvado, J Estruch, R Ros, E Alonso-Gomez, A Schroder, H Lapetra, J Serra-Majem, Ll Pinto, X Gutierrez-Bedmar, M Diaz-Lopez, A Gonzalez, J, I Fito, M Forga, L Fiol, M Romaguera, D |
Rights: | info:eu-repo/semantics/openAccess |
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