Repositori institucional URV
| URV's Author/s: | Capilla Luque, Javier / Guarro Artigas, Josep / Sanchis Talón, Marta |
| Author, as appears in the article.: | Sanchis M; Capilla J; Castanheira M; Martin-Vicente A; Sutton DA; Fothergill AW; Wiederhold NP; Guarro J |
| Author's mail: | marta.sanchis@urv.cat javier.capilla@urv.cat |
| Author identifier: | 0000-0001-7251-6792 0000-0002-0765-6403 |
| Journal publication year: | 2016 |
| Publication Type: | Journal Publications |
| ISSN: | 09248579 |
| APA: | Sanchis M; Capilla J; Castanheira M; Martin-Vicente A; Sutton DA; Fothergill AW; Wiederhold NP; Guarro J (2016). Voriconazole minimum inhibitory concentrations are predictive of treatment outcome in experimental murine infections by Candida glabrata. International Journal Of Antimicrobial Agents, 47(4), 286-288. DOI: 10.1016/j.ijantimicag.2015.12.020 |
| Papper original source: | International Journal Of Antimicrobial Agents. 47 (4): 286-288 |
| Abstract: | In this study, 27 clinical isolates of Candida glabrata with voriconazole (VRC) minimum inhibitory concentrations (MICs) ranging from ¿0.03 ¿g/mL to 8 ¿g/mL were tested to determine whether in vitro data are predictive of in vivo efficacy. The efficacy of VRC administered at 40 mg/kg was assayed in a neutropenic murine model of disseminated infection by C. glabrata. The reduction in fungal tissue burden in the kidneys was used as a marker of treatment efficacy. VRC reduced the fungal tissue burden in mice infected with strains that had MICs below the epidemiological cut-off value (ECV) of 0.25 ¿g/mL. Variable efficacy of VRC was obtained when the MIC equalled the ECV, and VRC was ineffective when the MIC exceeded the ECV. These results suggest that the use of in vitro data could be useful to predict the outcome for infections by this fungus. |
| Article's DOI: | 10.1016/j.ijantimicag.2015.12.020 |
| Link to the original source: | https://www.sciencedirect.com/science/article/abs/pii/S0924857916000431?via%3Dihub |
| Papper version: | info:eu-repo/semantics/acceptedVersion |
| licence for use: | https://creativecommons.org/licenses/by/3.0/es/ |
| Department: | Ciències Mèdiques Bàsiques |
| Licence document URL: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
| Thematic Areas: | Saúde coletiva Química Pharmacology (medical) Pharmacology & pharmacy Odontología Nutrição Microbiology (medical) Microbiology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Infectious diseases General medicine Farmacia Engenharias iii Engenharias ii Enfermagem Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Biotecnología Biodiversidade |
| Keywords: | Voriconazole Resistance Model Mechanisms Management Liposomal amphotericin-b Fungal infection Fluconazole Fks mutations Epidemiological cut-off value Efficacy Combination Caspofungin Candida glabrata Antifungals Animal model fungal infection epidemiological cut-off value candida glabrata antifungals animal model |
| Entity: | Universitat Rovira i Virgili |
| Record's date: | 2024-09-07 |
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