Repositori institucional URV
| URV's Author/s: | Capilla Luque, Javier / Guarro Artigas, Josep / Mayayo Artal, Emilio Manuel |
| Author, as appears in the article.: | Thomson P; Guarro J; Mayayo E; Capilla J |
| Author's mail: | javier.capilla@urv.cat |
| Author identifier: | 0000-0002-0765-6403 |
| Journal publication year: | 2015 |
| Publication Type: | Journal Publications |
| ISSN: | 00664804 |
| APA: | Thomson P; Guarro J; Mayayo E; Capilla J (2015). Efficacy of Posaconazole in a Murine Model of Systemic Infection by Saprochaete capitata. Antimicrobial Agents And Chemotherapy, 59(12), 7477-7482. DOI: 10.1128/AAC.01140-15 |
| Papper original source: | Antimicrobial Agents And Chemotherapy. 59 (12): 7477-7482 |
| Abstract: | The fungus Saprochaete capitata causes opportunistic human infections, mainly in immunocompromised patients with hematological malignancies. The best therapy for this severe infection is still unknown. We evaluated the in vitro killing activity and the in vivo efficacy of posaconazole at 5, 10, or 20 mg/kg twice a day (BID) in a murine neutropenic model of systemic infection with S. capitata by testing a set of six clinical isolates. Posaconazole showed fungistatic activity against all of the isolates tested. The different doses of the drug, especially the highest one, showed good efficacy, measured by prolonged survival, reduction of (1-3)-β-D-glucan levels in serum, tissue burden reduction, and histopathology. |
| Article's DOI: | 10.1128/AAC.01140-15 |
| Link to the original source: | https://aac.asm.org/content/59/12/7477 |
| Papper version: | info:eu-repo/semantics/acceptedVersion |
| licence for use: | https://creativecommons.org/licenses/by/3.0/es/ |
| Department: | Ciències Mèdiques Bàsiques |
| Licence document URL: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
| Thematic Areas: | Saúde coletiva Química Pharmacology (medical) Pharmacology & pharmacy Pharmacology Odontología Nutrição Microbiology Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Infectious diseases Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física |
| Entity: | Universitat Rovira i Virgili |
| Record's date: | 2024-09-07 |
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