Repositori institucional URV
| URV's Author/s: | Ardévol Grau, Anna / Blay Olivé, Maria Teresa / CASANOVA MARTÍ, ANGELA / GINÉS MIR, IRIS / Pinent Armengol, Montserrat / Terra Barbadora, Ximena |
| Author, as appears in the article.: | Ginés I, Gil-Cardoso K, Serrano J, Casanova-Martí À, Blay M, Pinent M, Ardévol A, Terra X. |
| Author's mail: | anna.ardevol@urv.cat ximena.terra@urv.cat mteresa.blay@urv.cat montserrat.pinent@urv.cat |
| Author identifier: | 0000-0003-0156-7538 0000-0003-1043-5844 0000-0002-6256-9847 0000-0003-3550-5378 |
| Journal publication year: | 2018 |
| Publication Type: | Journal Publications |
| ISSN: | 20726643 |
| e-ISSN: | 2072-6643 |
| APA: | Ginés I, Gil-Cardoso K, Serrano J, Casanova-Martí À, Blay M, Pinent M, Ardévol A, Terra X. (2018). Effects of an Intermittent Grape-Seed Proanthocyanidin (GSPE) Treatment on a Cafeteria Diet Obesogenic Challenge in Rats. Nutrients, 10(3), -. DOI: 10.3390/nu10030315 |
| Papper original source: | Nutrients. 10 (3): |
| Abstract: | Obesity is highly associated with the pathologies included in the concept of the Metabolic Syndrome. Grape-seed proanthocyanins (GSPE) have showed very positive effects against all these metabolic disruptions; however, there is, as yet, no consensus about their effectiveness against an obesogenic challenge, such as a cafeteria diet. We determined the effectiveness of a dose of 500 mg GSPE/kg b.w. (body weight) against the obesogenic effects of a 17-week cafeteria diet, administered as a sub-chronic treatment, 10-15 days before, intermittently and at the end of the diet, in Wistar rats. Body weight, adiposity, indirect calorimetry and plasma parameters were analyzed. GSPE pre-treatment showed a long-lasting effect on body weight and adiposity that was maintained for seven weeks after the last dose. A corrective treatment was administered for the last two weeks of the cafeteria diet intervention; however, it did not effectively correct any of the parameters assessed. The most effective treatment was an intermittent GSPE dosage, administered every second week during the cafeteria diet. This limited body weight gain, adiposity and most lipotoxic effects. Our results support the administration of this GSPE dose, keeping an intermittent interval between dosages longer than every second week, to improve obesogenic disruptions produced by a cafeteria diet. |
| Article's DOI: | 10.3390/nu10030315 |
| Link to the original source: | https://www.mdpi.com/2072-6643/10/3/315 |
| Papper version: | info:eu-repo/semantics/publishedVersion |
| licence for use: | https://creativecommons.org/licenses/by/3.0/es/ |
| Department: | Bioquímica i Biotecnologia |
| Licence document URL: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
| Thematic Areas: | Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología |
| Keywords: | Tumor necrosis factor-alpha Triglycerides Rats, wistar Rats Rat Proanthocyanidins Obesity Metabolic syndrome Insulin resistance Insulin Grape seed proanthocyanidins Grape seed extract Female Fatty acids, nonesterified Dose-response relationship, drug Dose Disease models, animal Diet Calorimetry, indirect Cafeteria-diet Body weight Body composition Blood glucose Antioxidants Animals Adiposity proanthocyanidins metabolic syndrome dose cafeteria-diet |
| Entity: | Universitat Rovira i Virgili |
| Record's date: | 2024-09-07 |
| First page: | 315 |
| Journal volume: | 10 |
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