Repositori institucional URV
| URV's Author/s: | BASAURE GARCÍA, PÍA ISABEL / Biosca Brull, Judit / Cabré Bargalló, Maria / Colomina Fosch, Maria Teresa / Domingo Roig, José Luis / Guardia Escoté, Laia |
| Author, as appears in the article.: | Guardia-Escote L; Basaure P; Peris-Sampedro F; Biosca-Brull J; Cabré M; Sánchez-Santed F; Domingo J; Colomina M |
| Author's mail: | mariateresa.colomina@urv.cat joseluis.domingo@urv.cat judit.biosca@urv.cat judit.biosca@urv.cat maria.cabre@urv.cat |
| Author identifier: | 0000-0002-5619-4874 0000-0001-6647-9470 0000-0003-4124-8603 |
| Journal publication year: | 2019 |
| Publication Type: | Journal Publications |
| ISSN: | 01664328 |
| APA: | Guardia-Escote L; Basaure P; Peris-Sampedro F; Biosca-Brull J; Cabré M; Sánchez-Santed F; Domingo J; Colomina M (2019). APOE genetic background and sex confer different vulnerabilities to postnatal chlorpyrifos exposure and modulate the response to cholinergic drugs. Behavioural Brain Research, 376(112195), 112195-112195. DOI: 10.1016/j.bbr.2019.112195 |
| Papper original source: | Behavioural Brain Research. 376 (112195): 112195-112195 |
| Abstract: | © 2019 Elsevier B.V. Chlorpyrifos (CPF) is an extensively used organophosphate pesticide. Exposure to CPF has been related to neurobehavioral disorders, particularly during neurodevelopment. Apolipoprotein E (apoE) is a lipid and cholesterol carrier and a susceptibility factor for cognitive impairment which can influence the response to toxic exposures. The study was aimed at assessing the effects of postnatal exposure to CPF on object recognition memory and its modulation by sex and APOE genotype. Human apoE3 and apoE4 targeted replacement mice and C57BL/6 mice were postnatally exposed to 0 or 1 mg/kg/day of CPF. Recognition memory was evaluated in an Object Recognition Test (ORT). In order to study the contribution of cholinergic and GABAergic neurotransmitter systems to recognition memory, a pharmacological challenge was included. Sex, genotype and postnatal exposure to CPF were key factors throughout the testing period. Specifically, CPF increased exploratory behavior and impaired discrimination performance. We observed that administering scopolamine, a cholinergic antagonist, was detrimental to recognition memory. However, discrimination in C57BL/6 and apoE4 males improved with the administration of the cholinergic agonist rivastigmine, but the same drug worsened retention in apoE4 females. Finally, the GABAergic agonist alprazolam altered performance in a sex- and genotype-dependent manner. Overall, these results suggest complex interactions between sex, APOE genotype and postnatal CPF exposure and indicate a different functioning of both the cholinergic and GABAergic neurotransmitter system between groups. |
| Article's DOI: | 10.1016/j.bbr.2019.112195 |
| Link to the original source: | https://www.sciencedirect.com/science/article/abs/pii/S0166432819308150?via%3Dihub |
| Papper version: | info:eu-repo/semantics/acceptedVersion |
| licence for use: | https://creativecommons.org/licenses/by/3.0/es/ |
| Department: | Bioquímica i Biotecnologia Ciències Mèdiques Bàsiques Psicologia |
| Licence document URL: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
| Thematic Areas: | Zootecnia / recursos pesqueiros Saúde coletiva Química Psychology Psicología Odontología Nutrição Neurosciences Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Filosofia/teologia:subcomissão filosofia Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciencias sociales Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência de alimentos Biotecnología Biodiversidade Behavioral sciences Behavioral neuroscience Administração pública e de empresas, ciências contábeis e turismo |
| Keywords: | Recognition memory Pesticide Cholinergic system Chlorpyrifos Brain development Apoe pesticide cholinergic system chlorpyrifos brain development apoe |
| Entity: | Universitat Rovira i Virgili |
| Record's date: | 2024-06-28 |
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