Repositori institucional URV
| URV's Author/s: | Miró Blanch, Joan / Yanes Torrado, Óscar |
| Author, as appears in the article.: | Miro-Blanch J, Yanes O |
| Author's mail: | oscar.yanes@urv.cat joan.miro@estudiants.urv.cat |
| Author identifier: | 0000-0003-3695-7157 0000-0003-3179-0554 |
| Journal publication year: | 2019 |
| Publication Type: | Journal Publications |
| ISSN: | 16648021 |
| APA: | Miro-Blanch J, Yanes O (2019). Epigenetic Regulation at the Interplay Between Gut Microbiota and Host Metabolism. Frontiers In Genetics, 10(JUL), 638-638. DOI: 10.3389/fgene.2019.00638 |
| Papper original source: | Frontiers In Genetics. 10 (JUL): 638-638 |
| Abstract: | Gut microbiota communities have coevolved for millions of years in a symbiotic relationship with their mammalian hosts. Elucidating and understanding the molecular mechanisms by which microbiota interacts with its host and how this contributes to the homeostasis of the host is crucial. One of these molecular relationships is the so-called chemical crosstalk between microbiota and host metabolisms, including the poorly explored epigenetic regulation of host tissues by the metabolic activity of gut microbiota in response to changes in diet. DNA methylation and histone modifications are epigenetic marks partly regulated by enzymes such as methylases and acetylases, whose activity depend on host and microbiota metabolites that act as substrates and cofactors for these reactions. However, providing a complete mechanistic description of the regulatory interactions between both metabolisms and the impact on the expression of host genes through an epigenetic modulation, remains elusive. This article presents our perspective on how metabolomic, metagenomic, transcriptomic, and epigenomic data can be used to investigate the "microbiota-nutrient metabolism-epigenetics axis." We also discuss the implications and opportunities this knowledge may have for basic and applied science, such as the impact on the way we structure future research, understand, and prevent diseases like type 2 diabetes or obesity. |
| Article's DOI: | 10.3389/fgene.2019.00638 |
| Link to the original source: | https://www.frontiersin.org/articles/10.3389/fgene.2019.00638/full |
| Papper version: | info:eu-repo/semantics/publishedVersion |
| licence for use: | https://creativecommons.org/licenses/by/3.0/es/ |
| Department: | Enginyeria Electrònica, Elèctrica i Automàtica |
| Licence document URL: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
| Thematic Areas: | Zootecnia / recursos pesqueiros Saúde coletiva Odontología Molecular medicine Medicina veterinaria Medicina ii Medicina i Interdisciplinar Genetics (clinical) Genetics & heredity Genetics Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência da computação Biotecnología Biodiversidade |
| Keywords: | Transplantation Transcription Posttranslational modifications Open chromatin Omics Microbiota Metabolomics Metabolism Impact Histones Epigenetics Donor feces Dna Diet-induced obesity Bacteria Acetylation |
| Entity: | Universitat Rovira i Virgili |
| Record's date: | 2023-05-21 |
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