Repositori institucional URV
| URV's Author/s: | Cilleros Mañé, Víctor / Garcia Sancho, Maria de les Neus / HURTADO CABALLERO, ERICA / Lanuza Escolano, María Angel / NADAL MAGRIÑÀ, LAURA / SIMÓ OLLÉ, ANNA / Tomás Ferré, José Maria / Tomas Marginet, Marta / TOMÀS ROIG, JORDI |
| Author, as appears in the article.: | Nadal L; Garcia N; Hurtado E; Simó A; Tomàs M; Lanuza M; Cilleros V; Tomàs J |
| Author's mail: | marta.tomas@urv.cat victor.cilleros@urv.cat josepmaria.tomas@urv.cat mariaangel.lanuza@urv.cat |
| Author identifier: | 0000-0002-4151-1697 0000-0001-5690-9932 0000-0002-0406-0006 0000-0003-4795-4103 |
| Journal publication year: | 2017 |
| Publication Type: | Journal Publications |
| ISSN: | 16634365 |
| APA: | Nadal L; Garcia N; Hurtado E; Simó A; Tomàs M; Lanuza M; Cilleros V; Tomàs J (2017). Presynaptic muscarinic acetylcholine receptors and TrkB receptor cooperate in the elimination of redundant motor nerve terminals during development. Frontiers In Aging Neuroscience, 9(FEB), 24-. DOI: 10.3389/fnagi.2017.00024 |
| Papper original source: | Frontiers In Aging Neuroscience. 9 (FEB): 24- |
| Abstract: | © 2017 Nadal, Garcia, Hurtado, Simó, Tomàs, Lanuza, Cilleros and Tomàs. The development of the nervous system involves the overproduction of synapses but connectivity is refined by Hebbian activity-dependent axonal competition. The newborn skeletal muscle fibers are polyinnervated but, at the end of the competition process, some days later, become innervated by a single axon. We used quantitative confocal imaging of the autofluorescent axons from transgenic B6.Cg-Tg (Thy1-YFP)16 Jrs/J mice to investigate the possible cooperation of the muscarinic autoreceptors (mAChR, M1-, M2- and M4-subtypes) and the tyrosine kinase B (TrkB) receptor in the control of axonal elimination after the mice Levator auris longus (LAL) muscle had been exposed to several selective antagonist of the corresponding receptor pathways in vivo. Our previous results show that M1, M2 and TrkB signaling individually increase axonal loss rate around P9. Here we show that although the M1 and TrkB receptors cooperate and add their respective individual effects to increase axonal elimination rate even more, the effect of the M2 receptor is largely independent of both M1 and TrkB receptors. Thus both, cooperative and non-cooperative signaling mechanisms contribute to developmental synapse elimination. |
| Article's DOI: | 10.3389/fnagi.2017.00024 |
| Link to the original source: | https://www.frontiersin.org/articles/10.3389/fnagi.2017.00024/full |
| Papper version: | info:eu-repo/semantics/publishedVersion |
| licence for use: | https://creativecommons.org/licenses/by/3.0/es/ |
| Department: | Ciències Mèdiques Bàsiques |
| Licence document URL: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
| Thematic Areas: | Saúde coletiva Química Psicología Nutrição Neurosciences Medicina veterinaria Medicina ii Medicina i Interdisciplinar Geriatrics & gerontology Engenharias iv Educação física Cognitive neuroscience Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Biodiversidade Aging |
| Keywords: | Trkb receptor Synapse elimination Presynaptic muscarinic acetylcholine receptors Neuromuscular junction Motor nerve terminal Cholinergic synapses trkb receptor presynaptic muscarinic acetylcholine receptors neuromuscular junction motor nerve terminal cholinergic synapses |
| Entity: | Universitat Rovira i Virgili |
| Record's date: | 2024-09-07 |
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