Repositori institucional URV
| URV's Author/s: | Ardévol Grau, Anna / Beltrán Debón, Raúl Alejandro / Blay Olivé, Maria Teresa / GONZALEZ QUILEN, CARLOS ALBERTO / Jorba Martin, Rosa Maria / Pinent Armengol, Montserrat / Terra Barbadora, Ximena |
| Author, as appears in the article.: | Grau-bové C; González-quilen C; Terra X; Teresa Blay M; Beltrán-Debón R; Jorba-martín R; Espina B; Pinent M; Ardévol A |
| Author's mail: | anna.ardevol@urv.cat ximena.terra@urv.cat mteresa.blay@urv.cat montserrat.pinent@urv.cat rosamaria.jorba@urv.cat raul.beltran@urv.cat |
| Author identifier: | 0000-0003-0156-7538 0000-0003-1043-5844 0000-0002-6256-9847 0000-0003-3550-5378 0000-0003-3307-4340 0000-0001-9691-1906 |
| Journal publication year: | 2020 |
| Publication Type: | Journal Publications |
| ISSN: | 2218273X |
| APA: | Grau-bové C; González-quilen C; Terra X; Teresa Blay M; Beltrán-Debón R; Jorba-martín R; Espina B; Pinent M; Ardévol A (2020). Effects of flavanols on enteroendocrine secretion. Biomolecules, 10(6), 1-14. DOI: 10.3390/biom10060844 |
| Papper original source: | Biomolecules. 10 (6): 1-14 |
| Abstract: | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Some beneficial effects of grape seed proanthocyanidin extract (GSPE) can be explained by the modulation of enterohormone secretion. As GSPE comprises a combination of different molecules, the pure compounds that cause these effects need to be elucidated. The enterohormones and chemoreceptors present in the gastrointestinal tract differ between species, so if humans are to gain beneficial effects, species closer to humans—and humans themselves—must be used. We demonstrate that 100 mg/L of GSPE stimulates peptide YY (PYY) release, but not glucagon-like peptide 1 (GLP-1) release in the human colon. We used a pig ex vivo system that differentiates between apical and basolateral intestinal sides to analyse how apical stimulation with GSPE and its pure compounds affects the gastrointestinal tract. In pigs, apical GSPE treatment stimulates the basolateral release of PYY in the duodenum and colon and that of GLP-1 in the ascending, but not the descending colon. In the duodenum, luminal stimulation with procyanidin dimer B2 increased PYY secretion, but not CCK secretion, while catechin monomers (catechin/epicatechin) significantly increased CCK release, but not PYY release. The differential effects of GSPE and its pure compounds on enterohormone release at the same intestinal segment suggest that they act through chemosensors located apically and unevenly distributed along the gastrointestinal tract. |
| Article's DOI: | 10.3390/biom10060844 |
| Link to the original source: | https://www.mdpi.com/2218-273X/10/6/844 |
| Papper version: | info:eu-repo/semantics/publishedVersion |
| licence for use: | https://creativecommons.org/licenses/by/3.0/es/ |
| Department: | Bioquímica i Biotecnologia |
| Licence document URL: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
| Thematic Areas: | Química Molecular biology Materiais General medicine Farmacia Ensino Biochemistry & molecular biology Biochemistry |
| Keywords: | Vitis Swine Seeds Pyy Procyanidins Proanthocyanidins Proanthocyanidin Plant extracts Pig Peptide yy Metabolism Intestine Humans Gut hormones Grape seed extract Glucagon-like peptide-1 Glucagon-like peptide 1 Glp-1 Ghrelin production Gastrointestinal tract Flavonoids Cholecystokinin Cells Cck Bitter Animals Absorption pyy glp-1 flavonoids cck |
| Entity: | Universitat Rovira i Virgili |
| Record's date: | 2024-07-27 |
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