Repositori institucional URV
| URV's Author/s: | Fernandez Veledo, Sonia / Maymo Masip, Elsa / Menacho Viladot, Margarita / Monfort Ferre, Diandra / Serena Perelló, Carolina / Vendrell Ortega, Juan José |
| Author, as appears in the article.: | Serena, Carolina; Queipo-Ortuno, Maribel; Millan, Monica; Sanchez-Alcoholado, Lidia; Caro, Aleidis; Espina, Beatriz; Menacho, Margarita; Bautista, Michelle; Monfort-Ferre, Diandra; Terron-Puig, Margarida; Nunez-Roa, Catalina; Maymo-Masip, Elsa; Mar Rodriguez, M; Tinahones, Francisco J; Espin, Eloy; Marti, Marc; Fernandez-Veledo, Sonia; Vendrell, Joan |
| Author's mail: | margarita.menacho@urv.cat carolina.serena@urv.cat elsa.maymo@urv.cat diandra.monfort@estudiants.urv.cat sonia.fernandez@urv.cat jvortega@iispv.cat |
| Author identifier: | 0000-0002-9133-3120 0000-0003-3832-4249 0000-0003-2906-3788 0000-0002-6994-6115 |
| Journal publication year: | 2020 |
| Publication Type: | Journal Publications |
| ISSN: | 20770383 |
| APA: | Serena, Carolina; Queipo-Ortuno, Maribel; Millan, Monica; Sanchez-Alcoholado, Lidia; Caro, Aleidis; Espina, Beatriz; Menacho, Margarita; Bautista, Mic (2020). Microbial Signature in Adipose Tissue of Crohn's Disease Patients. Journal Of Clinical Medicine, 9(8), 1-16. DOI: 10.3390/jcm9082448 |
| Paper original source: | Journal Of Clinical Medicine. 9 (8): 1-16 |
| Abstract: | Crohn's disease (CD) is characterized by compromised immune tolerance to the intestinal commensal microbiota, intestinal barrier inflammation, and hyperplasia of creeping fat (CF) and mesenteric adipose tissue (AT), which seems to be directly related to disease activity. Gut microbiota dysbiosis might be a determining factor in CD etiology, manifesting as a low microbial diversity and a high abundance of potentially pathogenic bacteria. We tested the hypothesis that CF is a reservoir of bacteria through 16S-rRNA sequencing of several AT depots of patients with active and inactive disease and controls. We found a microbiome signature within CF and mesenteric AT from patients, but not in subcutaneous fat. We failed to detect bacterial DNA in any fat depot of controls. Proteobacteria was the most abundant phylum in both CF and mesenteric AT, and positively correlated with fecal calprotectin/C-reactive protein. Notably, the clinical status of patients seemed to be related to the microbiome signature, as those with the inactive disease showed a reduction in the abundance of pathogenic bacteria. Predictive functional profiling revealed many metabolic pathways including lipopolysaccharide biosynthesis and sulfur metabolism overrepresented in active CD relative to that in inactive CD. Our findings demonstrate that microbiota dysbiosis associated with CD pathophysiology is reflected in AT and might contribute to disease severity. |
| Article's DOI: | 10.3390/jcm9082448 |
| Link to the original source: | https://www.mdpi.com/2077-0383/9/8/2448 |
| Paper version: | info:eu-repo/semantics/publishedVersion |
| licence for use: | https://creativecommons.org/licenses/by/3.0/es/ |
| Department: | Ciències Mèdiques Bàsiques |
| Licence document URL: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
| Thematic Areas: | Medicine, general & internal Medicine (miscellaneous) Medicine (all) |
| Keywords: | Ulcerative-colitis Tissue microbiota Stem-cells Picrust analysis Lipopolysaccharide biosynthesis Inflammatory bowel disease Inflammation Immune properties Ileostomy Gut microbiota Fusobacterium Fecal microbiota Escherichia coli Creeping fat Colorectal-cancer Colonic-mucosa 16s sequencing picrust analysis lipopolysaccharide biosynthesis inflammatory bowel disease fusobacterium escherichia coli creeping fat 16s sequencing |
| Entity: | Universitat Rovira i Virgili |
| Record's date: | 2025-02-01 |
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