Repositori institucional URV
| URV's Author/s: | Salas Salvadó, Jorge |
| Author, as appears in the article.: | Hernáez Á, Castañer O, Tresserra-Rimbau A, Pintó X, Fitó M, Casas R, Martínez-González MÁ, Corella D, Salas-Salvadó J, Lapetra J, Gómez-Gracia E, Arós F, Fiol M, Serra-Majem L, Ros E, Estruch R |
| Author's mail: | jordi.salas@urv.cat |
| Author identifier: | 0000-0003-2700-7459 |
| Journal publication year: | 2020 |
| Publication Type: | Journal Publications |
| ISSN: | 16134125 |
| APA: | Hernáez Á, Castañer O, Tresserra-Rimbau A, Pintó X, Fitó M, Casas R, Martínez-González MÁ, Corella D, Salas-Salvadó J, Lapetra J, Gómez-Gracia E, Arós (2020). Mediterranean Diet and Atherothrombosis Biomarkers: A Randomized Controlled Trial. Molecular Nutrition & Food Research, 64(2000350), e2000350-e2000350. DOI: 10.1002/mnfr.202000350 |
| Papper original source: | Molecular Nutrition & Food Research. 64 (2000350): e2000350-e2000350 |
| Abstract: | To assess whether following a Mediterranean diet (MedDiet) improved atherothrombosis biomarkers in high cardiovascular risk individuals.In 358 random volunteers from the PREvención con DIeta MEDiterránea trial, we assessed the 1-year effects on atherothrombosis markers of an intervention with MedDiet, enriched with virgin olive oil (MedDiet-VOO; n = 120) or nuts (MedDiet-Nuts; n = 119) versus a low-fat control diet (n = 119). We also studied whether large increments in MedDiet adherence (?3 score points, relative to compliance decreases) and intake changes in key food items were associated with 1-year differences in biomarkers. We observed differences between 1-year changes in the MedDiet-VOO intervention and control diet on the activity of platelet activating factor acetylhydrolase in HDLs (+7.5% [95% confidence interval: 0.17; 14.8]) and HDL-bound ?1 -antitrypsin levels (-6.1% [-11.8; -0.29]), and between the MedDiet-Nuts intervention and the control arm on non-esterified fatty acid concentrations (-9.3% [-18.1; -0.53]). Large MedDiet adherence increments were associated with less fibrinogen (-9.5% [-18.3; -0.60]) and non-esterified fatty acid concentrations (-16.7% [-31.7; -1.74]). Increases in nut, fruit, vegetable, and fatty fish consumption, and decreases in processed meat intake were linked to beneficial changes in atherothrombosis biomarkers.Following a MedDiet improved atherothrombosis biomarkers in high cardiovascular risk individuals. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved. |
| Article's DOI: | 10.1002/mnfr.202000350 |
| Link to the original source: | https://onlinelibrary.wiley.com/doi/10.1002/mnfr.202000350 |
| Papper version: | info:eu-repo/semantics/submittedVersion |
| licence for use: | https://creativecommons.org/licenses/by/3.0/es/ |
| Department: | Bioquímica i Biotecnologia |
| Licence document URL: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
| Thematic Areas: | Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física |
| Keywords: | Predictors Platelet Olive oil Mediterranean diet Mediterranean diet High-density-lipoprotein Fibrinogen Events Disease D-dimer Clinical trials Clinical trial Cardiovascular risk Biomarkers Biomarker Atherothrombosis Adherence |
| Entity: | Universitat Rovira i Virgili |
| Record's date: | 2023-02-19 |
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