Repositori institucional URV
| URV's Author/s: | Aranda Castel, Selena / FRANCO VÁSQUEZ, JOSÉ GABRIEL / Sepulveda Ramos, Esteban / Vilella Cuadrada, Elisabet |
| Author, as appears in the article.: | Sepulveda, Esteban; Adamis, Dimitrios; Franco, Jose G; Meagher, David; Aranda, Selena; Vilella, Elisabet |
| Author's mail: | esteban.sepulveda@urv.cat elisabet.vilella@urv.cat selena.aranda@estudiants.urv.cat |
| Author identifier: | 0000-0002-1887-5919 |
| Journal publication year: | 2021 |
| Publication Type: | Journal Publications |
| APA: | Sepulveda, Esteban; Adamis, Dimitrios; Franco, Jose G; Meagher, David; Aranda, Selena; Vilella, Elisabet (2021). The complex interaction of genetics and delirium: a systematic review and meta-analysis. European Archives Of Psychiatry And Clinical Neuroscience, 271(5), 929-939. DOI: 10.1007/s00406-021-01255-x |
| Papper original source: | European Archives Of Psychiatry And Clinical Neuroscience. 271 (5): 929-939 |
| Abstract: | The objective is to understand genetic predisposition to delirium. Following PRISMA guidelines, we undertook a systematic review of studies involving delirium and genetics in the databases of Pubmed, Scopus, Cochrane Library and PsycINFO, and performed a meta-analysis when appropriate. We evaluated 111 articles, of which 25 were finally included in the analysis. The studies were assessed by two independent researchers for methodological quality using the Downs and Black Tool and for genetic analysis quality. We performed a meta-analysis of 10 studies of the Apolipoprotein E (APOE) gene, obtaining no association with the presence of delirium (LOR 0.18, 95% CI - 0.10-0.47, p = 0.21). Notably, only 5 out of 25 articles met established criteria for genetic studies (good quality) and 6 were of moderate quality. Seven studies found an association with APOE4, the dopamine transporter gene SCL6A3, dopamine receptor 2 gene, glucocorticoid receptor, melatonin receptor and mitochondrial DNA haplotypes. One genome-wide association study found two suggestive long intergenic non-coding RNA genes. Five studies found no association with catechol-o-methyltransferase, melatonin receptor or several interleukins genes. The studies were heterogenous in establishing the presence of delirium. Future studies with large samples should further specify the delirium phenotype and deepen our understanding of interactions between genes and other biological factors. |
| Article's DOI: | 10.1007/s00406-021-01255-x |
| Link to the original source: | https://link.springer.com/article/10.1007/s00406-021-01255-x |
| Papper version: | info:eu-repo/semantics/acceptedVersion |
| licence for use: | https://creativecommons.org/licenses/by/3.0/es/ |
| Department: | Medicina i Cirurgia |
| Licence document URL: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
| Thematic Areas: | Saúde coletiva Psychiatry and mental health Psychiatry Psicología Pharmacology (medical) Medicine (miscellaneous) Medicina ii Medicina i Interdisciplinar Farmacia Engenharias iii Engenharias ii Clinical neurology Ciências biológicas ii Ciências biológicas i Biotecnología Biological psychiatry |
| Keywords: | Untranslated rna Test retest reliability Systematic review Single nucleotide polymorphism Scopus Retrospective study Restriction fragment length polymorphism Quality control Psycinfo Prospective study Preferred reporting items for systematic reviews and meta-analyses Neurotransmission Mitochondrial dna Middle aged Meta analysis Melatonin receptor Medline Male Interrater reliability Interleukin 8 Interleukin 6 receptor Intensive care unit Intensive care psychosis Humans Human Haplotype Glucocorticoid receptor Genome-wide association study Genetics Genetic predisposition to disease Genetic predisposition Genetic analysis Female Dopamine 2 receptor Disease association Dementia Delirium tremens Delirium Controlled study Confusion Cochrane library Catechol methyltransferase Biomarkers Article Apolipoprotein e4 Apolipoprotein e Amplified fragment length polymorphism Adult |
| Entity: | Universitat Rovira i Virgili |
| Record's date: | 2024-10-12 |
| Search your record at: |   |
| File | Description | Format | |
|---|---|---|---|
| DocumentPrincipal | DocumentPrincipal | application/pdf |
© 2011 Universitat Rovira i Virgili