Repositori institucional URV
| URV's Author/s: | Alkhoury, Nadine / Babio Sánchez, Nancy Elvira / Díaz López, Andres / Salas Salvadó, Jorge |
| Author, as appears in the article.: | Hernáez Á; Lassale C; Castro-Barquero S; Babio N; Ros E; Castañer O; Tresserra-Rimbau A; Pintó X; Martínez-González MÁ; Corella D; Salas-Salvadó J; Alonso-Gómez ÁM; Lapetra J; Fiol M; Gómez-Gracia E; Serra-Majem L; Sacanella E; García-Arellano A; Sorlí JV; Díaz-López A; Cofán M; Estruch R |
| Author's mail: | andres.diaz@urv.cat nadine.alkhoury@estudiants.urv.cat nadine.alkhoury@estudiants.urv.cat nadine.alkhoury@estudiants.urv.cat nadine.alkhoury@estudiants.urv.cat jordi.salas@urv.cat nancy.babio@urv.cat |
| Author identifier: | 0000-0002-7500-5629 0000-0003-2700-7459 0000-0003-3527-5277 |
| Journal publication year: | 2021 |
| Publication Type: | Journal Publications |
| APA: | Hernáez Á; Lassale C; Castro-Barquero S; Babio N; Ros E; Castañer O; Tresserra-Rimbau A; Pintó X; Martínez-González MÁ; Corella D; Salas-Salvadó J; Al (2021). Mediterranean diet and white blood cell count-a randomized controlled trial. Foods, 10(6), -. DOI: 10.3390/foods10061268 |
| Papper original source: | Foods. 10 (6): |
| Abstract: | We aimed to assess the effects of the antioxidant-rich Mediterranean diet (MedDiet) on white blood cell count. Our study population included participants in the PREvención con DIeta MEDiterránea study (average age 67 years old, 58% women, high cardiovascular risk). We assessed whether a MedDiet intervention enriched in extra-virgin olive oil or nuts, versus a low-fat control diet, modified the incidence of leukocytosis (>11 × 109 leukocytes/L), mild leukopenia (<4.5 × 109 leukocytes/L), or severe leukopenia (<3.5 × 109 leukocytes/L) in individuals without the condition at baseline (n = 3190, n = 2925, and n = 3190, respectively). We also examined whether MedDiet modified the association between leukocyte count alterations and all-cause mortality. Both MedDiet interventions were associated with a lower risk of developing leukopenia (incidence rates: 5.06% in control diet, 3.29% in MedDiet groups combined; hazard ratio [95% confidence interval]: 0.54 [0.36-0.80]) and severe leukopenia (incidence rates: 1.26% in control diet, 0.46% in MedDiet groups combined; hazard ratio: 0.25 [0.10-0.60]). High cumulative adherence to a MedDiet was linked to lower risk of leukocytosis (incidence rates: 2.08% in quartile 1, 0.65% in quartile 4; HRQ4-Q1: 0.29 [0.085-0.99]) and attenuated the association between leukopenia and all-cause mortality (Pinteraction = 0.032). In brief, MedDiet decreased the incidence of white blood cell count-related alterations in high cardiovascular risk individuals. |
| Article's DOI: | 10.3390/foods10061268 |
| Link to the original source: | https://www.mdpi.com/2304-8158/10/6/1268 |
| Papper version: | info:eu-repo/semantics/publishedVersion |
| licence for use: | https://creativecommons.org/licenses/by/3.0/es/ |
| Department: | Bioquímica i Biotecnologia |
| Licence document URL: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
| Thematic Areas: | Plant science Microbiology Health professions (miscellaneous) Health (social science) Food science & technology Food science |
| Keywords: | White blood cell count Randomized controlled trial Prevention Physical-activity questionnaire Mediterranean diet Leukopenia Leukocytosis randomized controlled trial prevention nutrition mortality mediterranean diet leukopenia leukocytosis leukocyte count inflammation high-cardiovascular risk health disease adults adherence |
| Entity: | Universitat Rovira i Virgili |
| Record's date: | 2024-07-27 |
| Journal volume: | 10 |
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| File | Description | Format | |
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| DocumentPrincipal | DocumentPrincipal | application/pdf |
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