Repositori institucional URV
| URV's Author/s: | Correig Blanchar, Francesc Xavier / Garcia-Altares Pérez, Maria / Ràfols Soler, Pere / Yanes Torrado, Óscar |
| Author, as appears in the article.: | Alexandra Iakab, Stefania; Rafols, Pere; Garcia-Altares, Maria; Yanes, Oscar; Correig, Xavier |
| Author's mail: | oscar.yanes@urv.cat maria.garcia-altares@urv.cat pere.rafols@urv.cat xavier.correig@urv.cat |
| Author identifier: | 0000-0003-3695-7157 0000-0002-9240-4058 0000-0002-6902-3054 |
| Journal publication year: | 2019 |
| Publication Type: | Journal Publications |
| APA: | Alexandra Iakab, Stefania; Rafols, Pere; Garcia-Altares, Maria; Yanes, Oscar; Correig, Xavier (2019). Silicon-Based Laser Desorption Ionization Mass Spectrometry for the Analysis of Biomolecules: A Progress Report. Advanced Functional Materials, 29(45), 1903609-. DOI: 10.1002/adfm.201903609 |
| Paper original source: | Advanced Functional Materials. 29 (45): 1903609- |
| Abstract: | Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) is widely used in the biomedical field for the label-free analysis of molecules such as drugs, lipids, peptides, proteins, and biological tissues for molecular imaging. However, organic matrices used in traditional MALDI-MS applications introduce excessive interferences in the low m/z range. For this reason, nanostructured materials-and in particular silicon-based LDI strategies-have become a promising alternative, since they provide a much weaker background. Herein, the recent developments in fabrication, functionalization, and practical applications of silicon-based LDI-MS methods are reviewed. Also the basic requirements of silicon-based substrates for optimal LDI analysis by providing an overview of the LDI mechanisms that use silicon-based substrates instead of organic matrices are reported. Finally, the considerable potential of silicon-based substrates is discussed, giving suggestions for topics for future research. |
| Article's DOI: | 10.1002/adfm.201903609 |
| Link to the original source: | https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.201903609 |
| Paper version: | info:eu-repo/semantics/acceptedVersion |
| licence for use: | https://creativecommons.org/licenses/by/3.0/es/ |
| Department: | Enginyeria Electrònica, Elèctrica i Automàtica |
| Licence document URL: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
| Thematic Areas: | Química Physics, condensed matter Physics, applied Nanoscience and nanotechnology Nanoscience & nanotechnology Materials science, multidisciplinary Materials science (miscellaneous) Materials science (all) Materiais General materials science General chemistry Engenharias iv Engenharias ii Electronic, optical and magnetic materials Electrochemistry Condensed matter physics Ciências agrárias i Chemistry, physical Chemistry, multidisciplinary Chemistry (miscellaneous) Chemistry (all) Biomaterials Astronomia / física |
| Keywords: | Surface functionalization Silver nanoparticles Silicon nanostructures Selective enrichment Nanowire arrays Nanostructure Ms analysis Modified porous silicon Mass spectrometry imaging (msi) Maldi Laser desorption ionization (ldi) Ion formation High-sensitivity Desorption/ionization |
| Entity: | Universitat Rovira i Virgili |
| Record's date: | 2024-10-12 |
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