Repositori institucional URV
| URV's Author/s: | BASAURE GARCÍA, PÍA ISABEL / Biosca Brull, Judit / Blanco Pérez, Jordi / Cabré Bargalló, Maria / Colomina Fosch, Maria Teresa / Domingo Roig, José Luis / Guardia Escoté, Laia |
| Author, as appears in the article.: | Biosca-Brull J; Guardia-Escote L; Blanco J; Basaure P; Cabré M; Sánchez-Santed F; Domingo JL; Colomina MT |
| Author's mail: | maria.cabre@urv.cat judit.biosca@urv.cat judit.biosca@urv.cat joseluis.domingo@urv.cat jordi.blanco@urv.cat mariateresa.colomina@urv.cat |
| Author identifier: | 0000-0003-4124-8603 0000-0001-6647-9470 0000-0001-8016-0984 0000-0002-5619-4874 |
| Journal publication year: | 2022 |
| Publication Type: | Journal Publications |
| APA: | Biosca-Brull J; Guardia-Escote L; Blanco J; Basaure P; Cabré M; Sánchez-Santed F; Domingo JL; Colomina MT (2022). Prenatal, but not postnatal exposure to chlorpyrifos affects social behavior of mice and the excitatory-inhibitory balance in a sex-dependent manner. Food And Chemical Toxicology, 169(), 113423-. DOI: 10.1016/j.fct.2022.113423 |
| Papper original source: | Food And Chemical Toxicology. 169 113423- |
| Abstract: | The balance between excitatory and inhibitory neurotransmitters is essential for proper brain development. An imbalance between these two systems has been associated with neurodevelopmental disorders. On the other hand, literature also associates the massive use of pesticides with the increase of these disorders, with a particular focus on chlorpyrifos (CPF) a world-wide used organophosphate pesticide. This study was aimed at assessing social autistic-like behaviors on mice pre or postnatally exposed to CPF (0 or 1 mg/kg/day), in both sexes. In prenatal exposure, C57BL/6J pregnant mice were exposed to CPF through the diet, between gestational days (GD) 12 and 18, while a positive control group for some autistic behaviors was exposed to valproic acid (VPA) on GD 12 and 13. To assess postnatal exposure, C57BL/6J mice were orally exposed to the vehicle (corn oil) or CPF, from postnatal days (PND) 10–15. Social behavior and gene expression analysis were assessed on PND 45. Results showed social alterations only in males prenatally treated. GABA system was upregulated in CPF-treated females, whereas an increase in both systems was observed in both treated males. These findings suggest that males are more sensitive to prenatal CPF exposure, favoring the sex bias observed in ASD. |
| Article's DOI: | 10.1016/j.fct.2022.113423 |
| Link to the original source: | https://www.sciencedirect.com/science/article/abs/pii/S0278691522006214?via%3Dihub |
| Papper version: | info:eu-repo/semantics/publishedVersion |
| licence for use: | https://creativecommons.org/licenses/by/3.0/es/ |
| Department: | Psicologia Ciències Mèdiques Bàsiques Bioquímica i Biotecnologia |
| Licence document URL: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
| Thematic Areas: | Toxicology Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física |
| Keywords: | Social behavior Glutamate Gaba Excitatory/inhibitory balance Chlorpyrifos Cerebellar purkinje-cells Autism social behavior receptor rat-brain messenger-rna levels inhibitory balance glutamate gene-expression gaba female mice excitatory developmental neurotoxicity brain-regions autism |
| Entity: | Universitat Rovira i Virgili |
| Record's date: | 2024-09-07 |
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