Repositori institucional URV
| URV's Author/s: | Bahadorikhalili, Saeed |
| Author, as appears in the article.: | Ebrahimi SM; Iradmousa MK; Rashed M; Fattahi Y; Ardakani YH; Bahadorikhalili S; Bafkary R; Erfan M; Dinarvand R; Mahboubi A |
| Author's mail: | saeed.bahadorikhalili@urv.cat |
| Author identifier: | 0000-0001-8047-342X |
| Journal publication year: | 2022 |
| Publication Type: | Journal Publications |
| APA: | Ebrahimi SM; Iradmousa MK; Rashed M; Fattahi Y; Ardakani YH; Bahadorikhalili S; Bafkary R; Erfan M; Dinarvand R; Mahboubi A (2022). Enzyme and Thermo Dual-Stimuli Responsive DOX Carrier Based on PNIPAM Conjugated Mesoporous Silica. Iranian Journal Of Pharmaceutical Research, 21(1), -. DOI: 10.5812/ijpr-130474 |
| Papper original source: | Iranian Journal Of Pharmaceutical Research. 21 (1): |
| Abstract: | Background: Stimuli-responsive drug delivery systems have been proven to be a promising strategy to enhance tumor localization, overcome multidrug resistance (MDR), and reduce the side effects of chemotherapy agents. Objectives: In this study, a temperature and redox dual stimuli-responsive system using mesoporous silica nanoparticles (MSNs) for targeted delivery of doxorubicin (DOX) was developed. Methods: Mesoporous silica nanoparticles were capped with poly(N-isopropylacrylamide) (PNIPAM), a thermo-sensitive polymer, with atom transfer radical polymerization (ATRP) method, via disulfide bonds (DOX-MSN-S-S-PNIPAM) to attain a controlled system that releases DOX under glutathione-rich (GSH-rich) environments and temperatures above PNIPAM’s lower critical solution temperature (LCST). Morphological and physicochemical properties of the nanoparticles were indicated using transmission electron microscopy (TEM), dynamic light scattering (DLS), energy-dispersive X-ray spectroscopy (EDS), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), and Brunauer-Emmett-Teller (BET). The drug release tests were performed at 25°C and 41°C in the absence and presence of the DTT, and the obtained results confirmed the synergic effect of temperature and reductive agent on a dual responsive release profile with a 73% cumulative release at 41°C and reductive environment during 240 min. Results: The average loaded drug content and encapsulation efficacy were reported as 42% and 29.5% at the drug: nanoparticle ratio of 1.5: 1. In vitro cytotoxicity assays on MCF-7 cell lines indicated significant viability decreased in cells exposed to DOX-MSN-S-S-PNIPAM compared to the free drug (DOX). Conclusions: Based on the results, DOX-MSN-S-S-PNIPAM has shown much more efficiency with stimuli-responsive properties in comparison to DOX on MCF-7 cancer cell lines. |
| Article's DOI: | 10.5812/ijpr-130474 |
| Link to the original source: | https://brieflands.com/articles/ijpr-130474.html |
| Papper version: | info:eu-repo/semantics/publishedVersion |
| licence for use: | https://creativecommons.org/licenses/by/3.0/es/ |
| Department: | Enginyeria Electrònica, Elèctrica i Automàtica |
| Licence document URL: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
| Thematic Areas: | Pharmacology, toxicology and pharmaceutics (miscellaneous) Pharmacology, toxicology and pharmaceutics (all) Pharmacology (medical) Pharmacology & pharmacy General pharmacology, toxicology and pharmaceutics |
| Keywords: | Stimuli-responsive Nanoparticles Drug-delivery Drug delivery Cancer Atrp polymerization stimuli-responsive release reduction polymerization nanoparticles drug delivery doxorubicin core copolymer cancer |
| Entity: | Universitat Rovira i Virgili |
| Record's date: | 2023-08-05 |
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