Repositori institucional URV
| URV's Author/s: | Babio Sánchez, Nancy Elvira / García Gavilán, Jesús Francisco / Nishi, Stephanie Kimiko / Paz Graniel, Indira del Socorro / Salas Salvadó, Jorge |
| Author, as appears in the article.: | García-Gavilán, J; Nishi, SK; Paz-Graniel, I; Guasch-Ferré, M; Razquin, C; Clish, CB; Toledo, E; Ruiz-Canela, M; Corella, D; Deik, A; Drouin-Chartier, JP; Wittenbecher, C; Babio, N; Estruch, R; Ros, E; Fitó, M; Arós, F; Fiol, M; Serra-Majem, L; Liang, LM; Martínez-González, MA; Hu, FB; Salas-Salvadó, J |
| Author's mail: | stephanie.nishi@urv.cat jesusfrancisco.garcia@urv.cat indiradelsocorro.paz@urv.cat jesusfrancisco.garcia@urv.cat indiradelsocorro.paz@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat |
| Author identifier: | 0000-0002-3204-6877 0000-0002-3204-6877 0000-0003-2700-7459 0000-0003-3527-5277 |
| Journal publication year: | 2022 |
| Publication Type: | Journal Publications |
| APA: | García-Gavilán, J; Nishi, SK; Paz-Graniel, I; Guasch-Ferré, M; Razquin, C; Clish, CB; Toledo, E; Ruiz-Canela, M; Corella, D; Deik, A; Drouin-Chartier, (2022). Plasma Metabolite Profiles Associated with the Amount and Source of Meat and Fish Consumption and the Risk of Type 2 Diabetes. Molecular Nutrition & Food Research, 66(23), e2200145-e2200145. DOI: 10.1002/mnfr.202200145 |
| Papper original source: | Molecular Nutrition & Food Research. 66 (23): e2200145-e2200145 |
| Abstract: | Scope Consumption of meat has been associated with a higher risk of type 2 diabetes (T2D), but if plasma metabolite profiles associated with these foods reflect this relationship is unknown. The objective is to identify a metabolite signature of consumption of total meat (TM), red meat (RM), processed red meat (PRM), and fish and examine if they are associated with T2D risk. Methods and results The discovery population includes 1833 participants from the PREDIMED trial. The internal validation sample includes 1522 participants with available 1-year follow-up metabolomic data. Associations between metabolites and TM, RM, PRM, and fish are evaluated with elastic net regression. Associations between the profiles and incident T2D are estimated using Cox regressions. The profiles included 72 metabolites for TM, 69 for RM, 74 for PRM, and 66 for fish. After adjusting for T2D risk factors, only profiles of TM (Hazard Ratio (HR): 1.25, 95% CI: 1.06-1.49), RM (HR: 1.27, 95% CI: 1.07-1.52), and PRM (HR: 1.27, 95% CI: 1.07-1.51) are associated with T2D. Conclusions The consumption of TM, its subtypes, and fish is associated with different metabolites, some of which have been previously associated with T2D. Scores based on the identified metabolites for TM, RM, and PRM show a significant association with T2D risk. |
| Article's DOI: | 10.1002/mnfr.202200145 |
| Link to the original source: | https://onlinelibrary.wiley.com/doi/10.1002/mnfr.202200145 |
| Papper version: | info:eu-repo/semantics/publishedVersion |
| licence for use: | https://creativecommons.org/licenses/by/3.0/es/ |
| Department: | Bioquímica i Biotecnologia |
| Licence document URL: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
| Thematic Areas: | Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física |
| Keywords: | Type 2 diabetes Risk factors Red meat Red Processed meat Predimed Physical-activity Metabolomics Metaanalysis Meat Foods Fishes Fish Diet Diabetes mellitus, type 2 Cardiovascular-disease Animals Amino-acids Acylcarnitines |
| Entity: | Universitat Rovira i Virgili |
| Record's date: | 2024-09-07 |
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