Repositori institucional URV
| URV's Author/s: | Cañellas Alberich, Nicolau / Correig Blanchar, Francesc Xavier |
| Author, as appears in the article.: | Escobar-Morreale, HF; Martínez-García, MA; Insenser, M; Cañellas, N; Correig, X; Luque-Ramírez, M |
| Author's mail: | xavier.correig@urv.cat nicolau.canyellas@urv.cat |
| Author identifier: | 0000-0002-6902-3054 0000-0003-4856-8132 |
| Journal publication year: | 2023 |
| Publication Type: | Journal Publications |
| APA: | Escobar-Morreale, HF; Martínez-García, MA; Insenser, M; Cañellas, N; Correig, X; Luque-Ramírez, M (2023). Serum metabolomics profiling by proton nuclear magnetic resonance spectroscopy reveals sexual dimorphism and masculinization of intermediate metabolism in women with polycystic ovary syndrome (PCOS). Biology Of Sex Differences, 14(1), 21-. DOI: 10.1186/s13293-023-00507-w |
| Papper original source: | Biology Of Sex Differences. 14 (1): 21- |
| Abstract: | Background: The polycystic ovary syndrome (PCOS) is associated with insulin resistance, obesity and cardiometabolic comorbidities. We here challenged the hypothesis, using state-of-the art proton nuclear magnetic resonance spectroscopy metabolomics profiling, that androgen excess in women induces also a certain masculinization of intermediate metabolism that is modulated by obesity. Methods: Participants were 53 Caucasian young adults, including 17 women with classic PCOS consisting of hyperandrogenism and ovulatory dysfunction, 17 non-hyperandrogenic women presenting with regular menses, and 19 healthy men, selected in order to be similar in terms of age and body mass index (BMI). Half of the subjects had obesity defined by a body mass index ≥ 30 kg/m2. Subjects maintained the same diet unrestricted in carbohydrates for 3 days before sampling and maintained their lifestyle and exercise patterns prior and during the study. Plasma samples were submitted to proton nuclear magnetic resonance spectroscopy metabolomics profiling. Results: Obesity associated a metabolomics profile mainly characterized by increased branched chain and aromatic aminoacids. Regardless of obesity, this unfavorable profile also characterized men as compared with control women, and was shared by women with PCOS. Notably, the negative impact of obesity on metabolomics profile was restricted to women, with obese men showing no further deterioration when compared with their non-obese counterparts. Conclusions: Serum metabolomics profiling by proton nuclear magnetic resonance spectroscopy reveals sexual dimorphism, and masculinization of intermediate metabolism in women with PCOS, further suggesting a role for sex and sex hormones in the regulation of intermediate metabolism. |
| Article's DOI: | 10.1186/s13293-023-00507-w |
| Link to the original source: | https://bsd.biomedcentral.com/articles/10.1186/s13293-023-00507-w |
| Papper version: | info:eu-repo/semantics/publishedVersion |
| licence for use: | https://creativecommons.org/licenses/by/3.0/es/ |
| Department: | Enginyeria Electrònica, Elèctrica i Automàtica |
| Licence document URL: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
| Thematic Areas: | Genetics & heredity Gender studies Endocrinology & metabolism Endocrinology Ciencias sociales Ciências biológicas ii |
| Keywords: | Subcutaneous adipose-tissue Sex Polycystic ovary syndrome Obesity Metabolism Estrogens Androgens sex prevalence polycystic ovary syndrome obesity obese women muscle mass metabolism mechanisms insulin-resistance glucose expression etiology estrogens androgen excess |
| Entity: | Universitat Rovira i Virgili |
| Record's date: | 2024-08-03 |
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