Repositori institucional URV
| URV's Author/s: | Salas Salvadó, Jorge |
| Author, as appears in the article.: | Wang, FL; Tessier, AJ; Liang, LM; Wittenbecher, C; Haslam, DE; Fernandez-Duval, G; Eliassen, AH; Rexrode, KM; Tobias, DK; Li, J; Zeleznik, O; Grodstein, F; Martinez-Gonzalez, MA; Salas-Salvado, J; Clish, C; Lee, KH; Sun, Q; Stampfer, MJ; Hu, FB; Guasch-Ferre, M |
| Author's mail: | jordi.salas@urv.cat |
| Author identifier: | 0000-0003-2700-7459 |
| Journal publication year: | 2023 |
| Publication Type: | Journal Publications |
| APA: | Wang, FL; Tessier, AJ; Liang, LM; Wittenbecher, C; Haslam, DE; Fernandez-Duval, G; Eliassen, AH; Rexrode, KM; Tobias, DK; Li, J; Zeleznik, O; Grodstei (2023). Plasma metabolomic profiles associated with mortality and longevity in a prospective analysis of 13,512 individuals. Nature Communications, 14(1), 5744-5744. DOI: 10.1038/s41467-023-41515-z |
| Papper original source: | Nature Communications. 14 (1): 5744-5744 |
| Abstract: | Experimental studies reported biochemical actions underpinning aging processes and mortality, but the relevant metabolic alterations in humans are not well understood. Here we examine the associations of 243 plasma metabolites with mortality and longevity (attaining age 85 years) in 11,634 US (median follow-up of 22.6 years, with 4288 deaths) and 1878 Spanish participants (median follow-up of 14.5 years, with 525 deaths). We find that, higher levels of N2,N2-dimethylguanosine, pseudouridine, N4-acetylcytidine, 4-acetamidobutanoic acid, N1-acetylspermidine, and lipids with fewer double bonds are associated with increased risk of all-cause mortality and reduced odds of longevity; whereas L-serine and lipids with more double bonds are associated with lower mortality risk and a higher likelihood of longevity. We further develop a multi-metabolite profile score that is associated with higher mortality risk. Our findings suggest that differences in levels of nucleosides, amino acids, and several lipid subclasses can predict mortality. The underlying mechanisms remain to be determined.© 2023. Springer Nature Limited. |
| Article's DOI: | 10.1038/s41467-023-41515-z |
| Link to the original source: | https://www.nature.com/articles/s41467-023-41515-z |
| Papper version: | info:eu-repo/semantics/publishedVersion |
| licence for use: | https://creativecommons.org/licenses/by/3.0/es/ |
| Department: | Bioquímica i Biotecnologia |
| Licence document URL: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
| Thematic Areas: | Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Physics and astronomy (miscellaneous) Physics and astronomy (all) Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Geociências General physics and astronomy General medicine General chemistry General biochemistry,genetics and molecular biology Farmacia Engenharias iv Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência da computação Chemistry (miscellaneous) Chemistry (all) Biotecnología Biodiversidade Biochemistry, genetics and molecular biology (miscellaneous) Biochemistry, genetics and molecular biology (all) Astronomia / física Antropologia / arqueologia |
| Keywords: | Incident cardiovascular-disease risk pseudouridine prevention ovarian-cancer mediterranean diet expression biomarkers all-cause mortality acylcarnitines |
| Entity: | Universitat Rovira i Virgili |
| Record's date: | 2024-08-03 |
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