Repositori institucional URV
| URV's Author/s: | Domingo Roig, José Luis / Nadal Lomas, Martí |
| Author, as appears in the article.: | Domingo JL; Nadal M |
| Author's mail: | joseluis.domingo@urv.cat marti.nadal@urv.cat |
| Author identifier: | 0000-0001-6647-9470 0000-0002-0217-4827 |
| Journal publication year: | 2025 |
| Publication Type: | Journal Publications |
| APA: | Domingo JL; Nadal M (2025). PCDD/Fs in human tissues: A review of global biomonitoring data.. Chemosphere, 377(), 144345-. DOI: 10.1016/j.chemosphere.2025.144345 |
| Paper original source: | Chemosphere. 377 144345- |
| Abstract: | This review investigates the concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in internal human organs and tissues - excluding blood - with a particular focus on adipose tissue studies conducted worldwide up to January 2025. A thorough analysis of published literature highlights significant geographical and temporal trends in human PCDD/F exposure, including potential associations between PCDD/F levels and various health conditions. Several research gaps are identified, and proposals for future studies are given. Studies from Europe, Asia, and North America demonstrated a general decline in tissue PCDD/F concentrations over recent decades, particularly from the 1970s to early 2000s, attributed to successful emission control measures. Adipose tissue PCDD/F levels were typically higher in industrialized regions, with occupational exposure studies showing significantly elevated concentrations compared to the general population. Notable regional variations were observed, with some Asian countries continuing to show relatively high PCDD/F levels despite the overall declining trend. The review also highlighted potential associations between PCDD/F exposure and various health conditions, including endometriosis and cryptorchidism, though causal relationships remain unclear. Physiologically Based Pharmacokinetic (PBPK) modeling studies estimate valuable insights into the distribution and accumulation of these compounds in human tissues. Research gaps identified include limited data from developing countries and other underrepresented regions. It is also important to acknowledge the variability in analytical methods and reporting units across the reviewed studies, which may complicate direct comparisons of results. This review emphasizes the importance of continued biomonitoring efforts, particularly in underrepresented regions, to track exposure trends and protect vulnerable populations. |
| Article's DOI: | 10.1016/j.chemosphere.2025.144345 |
| Link to the original source: | https://www.sciencedirect.com/science/article/pii/S0045653525002875 |
| Paper version: | info:eu-repo/semantics/publishedVersion |
| licence for use: | https://creativecommons.org/licenses/by/3.0/es/ |
| Department: | Ciències Mèdiques Bàsiques |
| Licence document URL: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
| Thematic Areas: | Zootecnia / recursos pesqueiros Saúde coletiva Química Public health, environmental and occupational health Pollution Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Materiais Interdisciplinar Health, toxicology and mutagenesis Geociências General chemistry Farmacia Environmental sciences Environmental engineering Environmental chemistry Ensino Engenharias iii Engenharias ii Engenharias i Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry (miscellaneous) Chemistry (all) Biotecnología Biodiversidade Astronomia / física |
| Keywords: | Polychlorinated dibenzodioxins Polychlorinated dibenzo-p-dioxins and dibenzofurans (pcdd/fs) Humans Human biomonitoring Global trends Exposure assessment Environmental pollutants Environmental exposure Dibenzofurans, polychlorinated Biological monitoring Benzofurans Adipose tissue |
| Entity: | Universitat Rovira i Virgili |
| Record's date: | 2025-04-30 |
| Search you record at: |  |
| File | Description | Format | |
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| DocumentPrincipal | DocumentPrincipal | application/pdf |
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