Repositori institucional URV
| URV's Author/s: | Plaza Diaz, Julio Ramon |
| Author, as appears in the article.: | Lizama-Munoz, Asier; Plaza-Diaz, Julio |
| Author's mail: | julioramon.plaza@urv.cat |
| Author identifier: | 0000-0002-5171-9408 |
| Journal publication year: | 2025 |
| Publication Type: | Journal Publications |
| APA: | Lizama-Munoz, Asier; Plaza-Diaz, Julio (2025). Bispecific Antibodies, Nanobodies and Extracellular Vesicles: Present and Future to Cancer Target Therapy. Biomolecules, 15(5), 639-. DOI: 10.3390/biom15050639 |
| Paper original source: | Biomolecules. 15 (5): 639- |
| Abstract: | Cancer remains one of the leading causes of mortality worldwide, with a growing need for precise and effective treatments. Traditional therapies such as chemotherapy and radiotherapy have limitations, including off-target effects and drug resistance. In recent years, targeted therapies have emerged as promising alternatives, aiming to improve treatment specificity and reduce systemic toxicity. Among the most innovative approaches, bispecific antibodies, nanobodies, and extracellular vesicles offer distinct and complementary mechanisms for cancer therapy. Bispecific antibodies enhance immune responses and enable dual-targeting of cancer cells, nanobodies provide superior tumor penetration due to their small size, and extracellular vesicles present a novel platform for drug and RNA delivery. This work aims to review and analyze these three approaches, assessing their current applications, advantages, challenges, and future perspectives. |
| Article's DOI: | 10.3390/biom15050639 |
| Link to the original source: | https://www.mdpi.com/2218-273X/15/5/639 |
| Paper version: | info:eu-repo/semantics/publishedVersion |
| licence for use: | https://creativecommons.org/licenses/by/3.0/es/ |
| Department: | Bioquímica i Biotecnologia |
| Licence document URL: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
| Thematic Areas: | Química Molecular biology Materiais General medicine Farmacia Ensino Biochemistry & molecular biology Biochemistry |
| Keywords: | Tria Target therapy Target therap Single-domain antibodies Neoplasms Nanobodies Molecular targeted therapy Humans Extracellular vesicles Engineering exosomes Egfr Drug delivery systems Cancer therapy Bispecific antibodies Biomarkers Antibodies, bispecific Animals |
| Entity: | Universitat Rovira i Virgili |
| Record's date: | 2025-06-07 |
| Search you record at: |  |
| File | Description | Format | |
|---|---|---|---|
| DocumentPrincipal | DocumentPrincipal | application/pdf |
© 2011 Universitat Rovira i Virgili