Author, as appears in the article.: Catalán Ú; Rubió L; López de Las Hazas M; Herrero P; Nadal P; Canela N; Pedret A; Motilva M; Solà R

Department: Medicina i Cirurgia Enginyeria Química

URV's Author/s: Catalán Santos, Úrsula / HERRERO GIL, POL / Pedret Figuerola, Anna / Solà Alberich, Rosa Maria

Keywords: Secoiridoids Proteome Hydroxytyrosol Healthy rats Cardiovascular disease proteome hydroxytyrosol healthy rats cardiovascular disease

Abstract: © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. SCOPE: Hydroxytyrosol (HT) is the major phenolic compound in virgin olive oil (VOO) in both free and complex forms (secoiridoids; SEC). Proteomics of cardiovascular tissues such as aorta or heart represents a promising tool to uncover the mechanisms of action of phenolic compounds in healthy animals.METHODS AND RESULTS: Twelve female Wistar rats were separated into three groups: a standard diet and two diets supplemented in phenolic compounds (HT and SEC) adjusted to 5 mg/kg/day during 21 days. Proteomic analyses of aorta and heart tissues were performed by nano-LC and MS. Ingenuity Pathway Analysis was used to generate interaction networks. HT or SEC modulated aorta and heart proteome compared to the standard diet. The top-scored networks were related to Cardiovascular System. HT and SEC downregulated proteins related to proliferation and migration of endothelial cells and occlusion of blood vessels in aorta and proteins related to heart failure in heart tissue. SEC showed higher fold change values compared to HT, attributed to higher concentration of HT detected in heart tissue.CONCLUSION: Changes at proteomic level in cardiovascular tissues may partially account for the underlying mechanisms of VOO phenols cardiovascular protection being the SEC effects higher than free HT.

Research group: Unitat de Recerca de Lípids i Arteriosclerosi

Thematic Areas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 16134125

Author's mail: ursula.catalan@urv.cat anna.pedret@urv.cat rosa.sola@urv.cat

Author identifier: 0000-0001-8884-9823 0000-0002-5327-932X 0000-0002-8359-235X

Record's date: 2023-02-19

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.201600052

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Molecular Nutrition & Food Research. 60 (10): 2114-2129

APA: Catalán Ú; Rubió L; López de Las Hazas M; Herrero P; Nadal P; Canela N; Pedret A; Motilva M; Solà R (2016). Hydroxytyrosol and its complex forms (secoiridoids) modulate aorta and heart proteome in healthy rats: Potential cardio-protective effects. Molecular Nutrition & Food Research, 60(10), 2114-2129. DOI: 10.1002/mnfr.201600052

Article's DOI: 10.1002/mnfr.201600052

Entity: Universitat Rovira i Virgili

Journal publication year: 2016

Publication Type: Journal Publications