Replication Data for: MASS2 - Modern Au-based Surfaces and Secondary ionisation for Mass Spectrometry Imaging of Small molecules

Bookmeyer, Christoph Hauke Manfred

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Replication Data for: MASS2 - Modern Au-based Surfaces and Secondary ionisation for Mass Spectrometry Imaging of Small molecules - PC:4160

Handle:

https://hdl.handle.net/20.500.11797/PC4160

Autor:	Bookmeyer, Christoph Hauke Manfred
Publicado por (editorial):	Universitat Rovira i Virgili (URV)
Acción del progama de financiación:	European Research Executive Agency (REA): HORIZON-MSCA-2021-PF-01 - 101067953
Tipo de documento:	info:eu-repo/semantics/other
Año de publicación de la dataset:	2024
Grupo de investigación:	Metabolomics Interdisciplary Laboratory
Identificador del investigador:	0000-0002-3479-3841
Publicaciones relacionadas:	Publication is in preparation.
Palabras clave:	MSI; MALDI; SALDI; SPICI
Idioma:	en
Departamento:	Enginyeria Electrònica, Elèctrica i Automàtica
Materia:	Chemistry; Medicine, Health and Life Sciences
Derechos de acceso:	info:eu-repo/semantics/openAccess
DOI:	10.34810/data1630
Título del conjunto de datos:	Replication Data for: MASS2 - Modern Au-based Surfaces and Secondary ionisation for Mass Spectrometry Imaging of Small molecules

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Descripción:	Measurement raw data, experimental descriptions, and protocols created during the MSCA-PF-01 101067953 MASS2 - SALDI-SPICI-MSI. Measurements and optimization of Au-based surface-assisted laser desorption/ionization mass spectrometry imaging combined with single-photon induced chemical ionization. The project aimed to develop a novel means for extensive metabolome and lipidome analysis by SALDI-PI-MSI to overcome limitations of MALDI. For this,we combined of a new PI strategy coined Single-Photon Induced Chemical Ionisation (SPICI) with functionalised Au layers. With this, the chemical coverage of compounds in biomedical tissue sections could be extended, especially for an extended mass range below 500 Da, and with high mass and spatial resolution. The parameter were optimised and key settings for a comprehensive analysis identified. As a result, a large number of endogenous analytes were detected that could not be detected with conventional MALDI-MSI or SALDI-MSI systems before. Complex data outputs were analyzed with the versatile in-house developed software package rMSI that facilitated routine data mining. The new technical possibilities were demonstrated in the analysis and comprehensive spatial biochemical characterisation of zebra fish embryos. This can now serve as a fast and scalable template for, e.g., future toxicology/exposome studies. (2024-05-31)
Tipo:	info:eu-repo/semantics/other
Títol:	Replication Data for: MASS2 - Modern Au-based Surfaces and Secondary ionisation for Mass Spectrometry Imaging of Small molecules
Coautor:	Enginyeria Electrònica, Elèctrica i Automàtica Metabolomics Interdisciplary Laboratory
Materia:	Chemistry; Medicine, Health and Life Sciences MSI; MALDI; SALDI; SPICI
Fecha:	2024
Idioma:	en
Formato:	Universitat Rovira i Virgili (URV)
Autor:	Bookmeyer, Christoph Hauke Manfred
Derechos:	info:eu-repo/semantics/openAccess
Editor:	Universitat Rovira i Virgili (URV)
Fecha alta repositorio:	2024-09-13

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