Repositori institucional URV
| URV's Author/s: | Domingo Roig, José Luis / FABREGA BONADONA, FRANCESC / GARCÍA ESTARLICH, FRANCISCO / García Sayago, Francisco / Kumar, Vikas / Nadal Lomas, Martí / Schuhmacher Ansuategui, Marta |
| Author, as appears in the article.: | Schuhmacher, Marta; Fabrega, Francesc; Kumar, Vikas; Garcia, Francisco; Nadal, Marti; Domingo, Jose L |
| Author's mail: | vikas.kumar@urv.cat francisco.garcia@urv.cat joseluis.domingo@urv.cat marti.nadal@urv.cat marta.schuhmacher@urv.cat |
| Author identifier: | 0000-0002-9795-5967 0000-0003-0594-8370 0000-0001-6647-9470 0000-0002-0217-4827 0000-0003-4381-2490 |
| Journal publication year: | 2014 |
| Publication Type: | Journal Publications |
| ISSN: | 01604120 |
| APA: | Schuhmacher, Marta; Fabrega, Francesc; Kumar, Vikas; Garcia, Francisco; Nadal, Marti; Domingo, Jose L (2014). A PBPK model to estimate PCDD/F levels in adipose tissue: Comparison with experimental values of residents near a hazardous waste incinerator. Environment International, 73(), 150-157. DOI: 10.1016/j.envint.2014.07.020 |
| Paper original source: | Environment International. 73 150-157 |
| Abstract: | This study was aimed at determining the concentrations of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) in 15 samples of adipose tissue from subjects who had been living in the vicinity of a hazardous waste incinerator (HWI). The results were compared with levels obtained in previous surveys carried out in 1998 (baseline study), 2002 and 2007. The current (2013) concentrations of PCDD/Fs in adipose tissue ranged from 2.8 to 46.3 pg WHO-TEQ/g fat (mean and median concentrations: 11.5 and 7.4 pg WHO-TEQ/g fat, respectively), being significantly lower (64%) than those observed in 1998. In contrast, no significant differences in the mean PCDD/F concentrations were noted in the period 2002-2013. The significant decrease of the PCDD/F content in fat, also noted in other biological monitors such as plasma and breast milk, is in agreement with the reduction in the dietary intake of PCDD/Fs found in the same area of study. Similarly to other investigations across Europe, an increase of PCDD/F levels in adipose tissue in relation to age was observed, while no significant differences were noted according to gender. A multicompartmental physiologically-based pharmacokinetic (PBPK) model was also applied to estimate the levels of PCDD/Fs in adipose tissue. When comparing the modeled and experimental concentrations of PCDD/Fs in that tissue, very similar values were obtained for the four surveys, which indicates this can be a reliable tool to predict the internal dose of PCDD/Fs.Copyright © 2014 Elsevier Ltd. All rights reserved. |
| Article's DOI: | 10.1016/j.envint.2014.07.020 |
| Link to the original source: | https://www.sciencedirect.com/science/article/pii/S0160412014002414?via%3Dihub |
| Paper version: | info:eu-repo/semantics/publishedVersion |
| licence for use: | https://creativecommons.org/licenses/by/3.0/es/ |
| Department: | Enginyeria Química Ciències Mèdiques Bàsiques |
| Licence document URL: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
| Thematic Areas: | Zootecnia / recursos pesqueiros Saúde coletiva Química Medicina iii Medicina ii Medicina i Interdisciplinar Geociências General medicine General environmental science Farmacia Environmental sciences Environmental science (miscellaneous) Environmental science (all) Engenharias iv Engenharias ii Engenharias i Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Biotecnología Biodiversidade Astronomia / física Administração pública e de empresas, ciências contábeis e turismo |
| Keywords: | Temporal trend Polychlorinated dibenzodioxins Physiologically-based pharmacokinetic (pbpk) model Pharmacokinetics Pcdd/fs Pbpk model Models, biological Milk, human Middle aged Male Incineration Humans Hazardous waste incinerator Hazardous waste Female Dibenzofurans, polychlorinated Benzofurans Air pollutants Aged Adult Adipose tissue pcdd/fs pbpk model hazardous waste incinerator adipose tissue |
| Entity: | Universitat Rovira i Virgili |
| Record's date: | 2025-02-08 |
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