Repositori institucional URV
| URV's Author/s: | CABRÉ LLOBET, ANNA / Castro Salomó, Antoni / FERRÉ VALLÈS, RAIMON / HERAS IBAÑEZ, MERCEDES / Marimon Cortes, Francesc / Masana Marín, Luis / Parra Pérez, Sandra / Ribalta Vives, Josep |
| Author, as appears in the article.: | Parra, S; Cabré, A; Marimon, F; Ferré, R; Ribalta, J; Gonzàlez, M; Heras, M; Castro, A; Masana, L |
| Author's mail: | francesc.marimon@urv.cat sandra.parra@urv.cat antoni.castro@urv.cat luis.masana@urv.cat josep.ribalta@urv.cat |
| Author identifier: | 0000-0001-9363-6574 0000-0001-5441-6333 0000-0002-0789-4954 0000-0002-8879-4719 |
| Journal publication year: | 2014 |
| Publication Type: | Journal Publications |
| ISSN: | 09612033 |
| APA: | Parra, S; Cabré, A; Marimon, F; Ferré, R; Ribalta, J; Gonzàlez, M; Heras, M; Castro, A; Masana, L (2014). Circulating FABP4 is a marker of metabolic and cardiovascular risk in SLE patients. Lupus, 23(3), 245-254. DOI: 10.1177/0961203313517405 |
| Papper original source: | Lupus. 23 (3): 245-254 |
| Abstract: | The aim of this study is to determine if circulating fatty acid-binding protein 4 (FABP4) plasma levels are a possible marker of metabolic risk in SLE patients. Circulating levels of adipose FABP4 are associated with adiposity, insulin resistance (IR), metabolic syndrome, diabetes and cardiovascular diseases. Patients affected by systemic lupus erythematosus (SLE) show an accelerated atherosclerosis that cannot be entirely explained by traditional cardiovascular risk factors. Sixty consecutive patients with SLE and 34 non-SLE age-matched controls were recruited for the study. Total plasma lipids and circulating FABP4 were determined. Subclinical atherosclerosis was evaluated by measuring carotid intimae-media thickness (c-IMT) by sonography, and the distribution of lipoprotein subclasses was analysed by nuclear magnetic resonance (NMR) spectroscopy. In the SLE group, FABP4 was associated with IR, atherogenic dyslipidaemia, as measured by NMR, and the presence of subclinical atherosclerosis. In multivariate analyses FABP4 was associated with increased c-IMT independent of the inflammatory state of the patient. In sum, circulating FABP4 is involved in the metabolic disturbances of SLE affecting lipid metabolism and IR, and it could be a biomarker of atherosclerosis in this population. |
| Article's DOI: | 10.1177/0961203313517405 |
| Link to the original source: | https://journals.sagepub.com/doi/10.1177/0961203313517405 |
| Papper version: | info:eu-repo/semantics/submittedVersion |
| licence for use: | https://creativecommons.org/licenses/by/3.0/es/ |
| Department: | Medicina i Cirurgia |
| Licence document URL: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
| Thematic Areas: | Zootecnia / recursos pesqueiros Saúde coletiva Rheumatology Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Antropologia / arqueologia |
| Keywords: | Systemic lupus erythematosus Spain Risk factors Prognosis Prevalence Multivariate analysis Middle aged Metabolic syndrome Magnetic resonance spectroscopy Lupus erythematosus, systemic Lipids Linear models Humans Haematologic Female Fatty acid-binding proteins Fabp4 protein, human Cross-sectional studies Changes Case-control studies Carotid intima-media thickness Carotid artery diseases Cardiovascular disease Biomarkers Asymptomatic diseases Aged Adult systemic lupus erythematosus changes cardiovascular disease |
| Entity: | Universitat Rovira i Virgili |
| Record's date: | 2025-01-08 |
| Search your record at: |   |
| File | Description | Format | |
|---|---|---|---|
| DocumentPrincipal | DocumentPrincipal | application/pdf |
© 2011 Universitat Rovira i Virgili