Repositori institucional URV
| URV's Author/s: | Castro Salomó, Antoni / FERRÉ VALLÈS, RAIMON / Guardiola Guionnet, Montserrat / Parra Pérez, Sandra / Ribalta Vives, Josep |
| Author, as appears in the article.: | Parra, Sandra; Vives, Gloria; Ferre, Raimon; Gonzalez, Marta; Guardiola, Montse; Ribalta, Josep; Castro, Antoni |
| Author's mail: | sandra.parra@urv.cat antoni.castro@urv.cat montse.guardiola@urv.cat josep.ribalta@urv.cat |
| Author identifier: | 0000-0001-9363-6574 0000-0001-5441-6333 0000-0002-9696-7384 0000-0002-8879-4719 |
| Journal publication year: | 2012 |
| Publication Type: | Journal Publications |
| ISSN: | 00219150 |
| APA: | Parra, Sandra; Vives, Gloria; Ferre, Raimon; Gonzalez, Marta; Guardiola, Montse; Ribalta, Josep; Castro, Antoni (2012). Complement system and small HDL particles are associated with subclinical atherosclerosis in SLE patients. Atherosclerosis, 225(1), 224-230. DOI: 10.1016/j.atherosclerosis.2012.08.029 |
| Papper original source: | Atherosclerosis. 225 (1): 224-230 |
| Abstract: | The complement system is involved in the pathogenic course of SLE. These patients exhibit metabolic disturbances in lipoprotein metabolism characterized by a pro-inflammatory status and an accelerated atherosclerosis. The aim of this study is to investigate whether levels of the complement are associated to the presence of subclinical atherosclerosis, lipid and glucose metabolism and inflammatory markers in SLE patients.Sixty-nine consecutive patients with SLE were recruited for the study. Fasting venous blood samples were collected on the same day as the measurements of cIMT were performed. Total plasma lipids and the distribution of subclasses of lipoproteins were analyzed by nuclear magnetic resonance spectroscopy.We found direct correlations between cIMT values and the levels of C3, C4 and CH50. In multivariate analyses, the mean cIMT from the three territories were predicted by age (? = 0.005, 95% CI: 0.002-0.007, P < 0.001) and the functional hemolytic assay of the complement activity CH50 (? = 0.003, 95% CI: 0.001-0.006, P < 0.0013). The complement components were associated with BMI, SBP and levels of glucose. Small, dense HDL particles also correlated with the three complement components C3, C4 and CH50 in bivariate analyses. In multivariate analyses small HDL particles predicted levels of C3: ? = 0.024, 95% CI: 0.013-0.035, P < 0.001; and C4: ? = 0.005, 95% CI: 0.002-0.008, P = 0.006.Activation of the complement system measured by functional assay CH50 is related to subclinical atherosclerosis in quiescent lupus patients and is activated by the small dense HDL particles.Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. |
| Article's DOI: | 10.1016/j.atherosclerosis.2012.08.029 |
| Link to the original source: | https://www.atherosclerosis-journal.com/article/S0021-9150(12)00578-3/fulltext |
| Papper version: | info:eu-repo/semantics/submittedVersion |
| licence for use: | https://creativecommons.org/licenses/by/3.0/es/ |
| Department: | Medicina i Cirurgia |
| Licence document URL: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
| Thematic Areas: | Saúde coletiva Psicología Peripheral vascular disease Odontología Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Ciência da computação Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología Antropologia / arqueologia |
| Keywords: | Small hdl particles Middle aged Male Lupus erythematosus, systemic Lupus Lipoproteins, hdl Lipids Intimal medial thickness Humans Female Etiology Complement system proteins Complement hemolytic activity assay Complement c4 Complement c3 Complement Carotid intima-media thickness Blood Atherosclerosis Adult |
| Entity: | Universitat Rovira i Virgili |
| Record's date: | 2025-01-08 |
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