Repositori institucional URV
| URV's Author/s: | ECHAVARREN PABLOS, ANTONIO |
| Author, as appears in the article.: | Dorel, Ruth; Echavarren, Antonio M |
| Author's mail: | antoniomaria.echavarren@urv.cat |
| Author identifier: | 0000-0002-6418-7930 |
| Journal publication year: | 2015 |
| Publication Type: | Journal Publications |
| APA: | Dorel, Ruth; Echavarren, Antonio M (2015). Gold(I)-Catalyzed Activation of Alkynes for the Construction of Molecular Complexity. Chemical Reviews, 115(17), 9028-9072. DOI: 10.1021/cr500691k |
| Papper original source: | Chemical Reviews. 115 (17): 9028-9072 |
| Abstract: | Gold(I) complexes are the most effective catalysts for the electrophilic activation of alkynes under homogeneous conditions, and a broad range of versatile synthetic tools have been developed for the construction of carbon-carbon or carbon-heteroatom bonds. The properties of gold (I) complexes can be easily tuned sterically or electronically depending on the ligand, consequently modulating their reactivity in the activation of alkynes, alkenes, and allenes. Reactions catalyzed by gold (I) are similar to those catalyzed by other electrophilic metal complexes or even BrOønsted acids and resemble carbocation-mediated processes. However, gold (I) provides unique control on complex transformations by very selectively activating alkynes and by stabilizing the key carbocationic intermediates by weak, but still significant, metal to carbene πback-donation. Additionally, the structural characteristics of linear two-coordinated gold (I) complexes, in which the ligand is very distant from the nucleophilic addition site to the πbound substrate, explains the slow development of general enantioselective transformations of alkynes. |
| Article's DOI: | 10.1021/cr500691k |
| Link to the original source: | https://pubs.acs.org/doi/10.1021/cr500691k |
| Papper version: | info:eu-repo/semantics/publishedVersion |
| licence for use: | https://creativecommons.org/licenses/by/3.0/es/ |
| Department: | Química Analítica i Química Orgànica |
| Licence document URL: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
| Thematic Areas: | Química Materiais General medicine General chemistry Farmacia Engenharias iii Engenharias ii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Chemistry, multidisciplinary Chemistry (miscellaneous) Chemistry (all) Chemistry Biotecnología |
| Keywords: | Ugi intramolecular hydroarylation Silyl enol ethers One-pot synthesis N-heterocyclic carbene Migration/intramolecular 3+2 cycloaddition Highly diastereoselective formation Gold-catalyzed cycloisomerization Enantioselective total-synthesis Dynamic solution behavio Abnormal nhc-gold(i) complexes |
| Entity: | Universitat Rovira i Virgili |
| Record's date: | 2024-11-09 |
| Search your record at: |   |
| File | Description | Format | |
|---|---|---|---|
| DocumentPrincipal | DocumentPrincipal | application/pdf |
© 2011 Universitat Rovira i Virgili