Presynaptic muscarinic acetylcholine autoreceptors (M1, M2 and M4 subtypes), adenosine receptors (A1 and A2A) and tropomyosin-related kinase B receptor (TrkB) modulate the developmental synapse elimination process at the neuromuscular junction

Marta Tomàs; Laura Nadal; Neus Garcia; Erica Hurtado; Anna Simó; Maria A. Lanuza; Manel Santafé; Josep Tomàs

TÍTOL:

Presynaptic muscarinic acetylcholine autoreceptors (M1, M2 and M4 subtypes), adenosine receptors (A1 and A2A) and tropomyosin-related kinase B receptor (TrkB) modulate the developmental synapse elimination process at the neuromuscular junction - PC:1791

Handle:

https://hdl.handle.net/20.500.11797/PC1791

Autor/s de la URV:	Tomas Marginet, Marta; Laura Nadal; Neus Garcia; Erica Hurtado; Anna Simó; LANUZA ESCOLANO, MARÍA ANGEL; SANTAFÉ MARTÍNEZ, MANUEL; Josep Tomàs
Autor segons l'article:	Marta Tomàs; Laura Nadal; Neus Garcia; Erica Hurtado; Anna Simó; Maria A. Lanuza; Manel Santafé; Josep Tomàs
Any de publicació de la revista:	2016
Tipus de publicació:	Article
ISSN:	1756-6606
e-ISSN:	1756-6606
DOI de l'article:	https://doi.org/10.1186/s13041-016-0248-9
Enllaç font original:	https://molecularbrain.biomedcentral.com/articles/10.1186/s13041-016-0248-9
Versió de l'article dipositat:	info:eu-repo/semantics/publishedVersion
Accès a la llicència d'ús:	thttps://creativecommons.org/licenses/by/3.0/es/
Departament:	Ciències Mèdiques Bàsiques
Grup de recerca:	Unitat d'Histologia i Neurobiologia
URL Document de llicència:	https://repositori.urv.cat/ca/proteccio-de-dades/
Àrees temàtiques:	Ciències de la salut
Entitat:	Universitat Rovira i Virgili
Data d'alta del registre:	2016-07-25
Pàgina inicial:	67
Volum de revista:	9

Descripció:	The development of the nervous system involves an initially exuberant production of neurons that make an excessive number of synaptic contacts. The initial overproduction of synapses promotes connectivity. Hebbian competition between axons with different activities (the least active are punished) leads to the loss of roughly half of the overproduced elements and this refines connectivity and increases specificity. The neuromuscular junction is innervated by a single axon at the end of the synapse elimination process and, because of its relative simplicity, has long been used as a model for studying the general principles of synapse development. The involvement of the presynaptic muscarinic ACh autoreceptors may allow for the direct competitive interaction between nerve endings through differential activity-dependent acetylcholine release in the synaptic cleft. Then, the most active ending may directly punish the less active ones. Our previous results indicate the existence in the weakest axons on the polyinnervated neonatal NMJ of an ACh release inhibition mechanism based on mAChR coupled to protein kinase C and voltage-dependent calcium channels. We suggest that this mechanism plays a role in the elimination of redundant neonatal synapses. Results: Here we used confocal microscopy and quantitative morphological analysis to count the number of brightly fluorescent axons per endplate in P7, P9 and P15 transgenic B6.Cg-Tg (Thy1-YFP)16 Jrs/J mice. We investigate the involvement of individual mAChR M1-, M2- and M4-subtypes in the control of axonal elimination after the Levator auris longus muscle had been exposed to agonist and antagonist in vivo. We also analysed the role of adenosine receptor subtypes (A1 and A2A) and the tropomyosin-related kinase B receptor. The data sh
Cobertura:	Anglès
Tipus:	Article Artículo Article info:eu-repo/semantics/publishedVersion
Coautor:	Unitat d'Histologia i Neurobiologia Ciències Mèdiques Bàsiques Universitat Rovira i Virgili
Títol:	Presynaptic muscarinic acetylcholine autoreceptors (M1, M2 and M4 subtypes), adenosine receptors (A1 and A2A) and tropomyosin-related kinase B receptor (TrkB) modulate the developmental synapse elimination process at the neuromuscular junction
Matèria:	Cellular and Molecular Neuroscience; Molecular Biology; Neurosciences motor nerve terminal motor end-plate cholinergic synapses Health sciences Ciencias de la salud Ciències de la salut 1756-6606
Data:	2016
Format:	2964 kb
Autor:	Marta Tomàs Laura Nadal Neus Garcia Erica Hurtado Anna Simó Maria A. Lanuza Manel Santafé Josep Tomàs
Drets:	info:eu-repo/semantics/openAccess

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